{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T12:52:24Z","timestamp":1783774344527,"version":"3.55.0"},"reference-count":13,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,1,16]],"date-time":"2013-01-16T00:00:00Z","timestamp":1358294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Our aim is to implement a simple, rapid, and reliable method using computed tomography perfusion imaging and clinical judgment to target patients for reperfusion therapy in the hyper\u2010acute stroke setting. We introduce a novel formula (1\u2013infarct volume [CBV]\/penumbra volume [MTT] \u00d7 100%) to quantify mismatch percentage.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Twenty patients with anterior circulation strokes who underwent CT perfusion and received intravenous tissue plasminogen activator (IV tPA) were analyzed retrospectively. Nine blinded viewers determined volume of infarct and ischemic penumbra using the ABC\/2 method and also the mismatch percentage.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Interrater reliability using the volumetric formula (ABC\/2) was very good (intraclass correlation [ICC] = .9440 and ICC = .8510) for hemodynamic parameters infarct (CBV) and penumbra (MTT). ICC coefficient using the mismatch formula (1\u2013MTT\/CBV \u00d7 100%) was good (ICC of .635).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>The ABC\/2 method of volume estimation on CT perfusion is a reliable and efficient approach to determine infarct and penumbra volumes. The 1\u2013CBV\/MTT \u00d7 100% formula produces a mismatch percentage assisting providers in communicating the proportion of salvageable brain and guides therapy in the setting of patients with unclear time of onset with potentially salvageable tissue who can undergo mechanical retrieval or intraarterial thrombolytics.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jon.12001","type":"journal-article","created":{"date-parts":[[2013,1,16]],"date-time":"2013-01-16T19:57:15Z","timestamp":1358366235000},"page":"232-237","source":"Crossref","is-referenced-by-count":8,"title":["Reproducibility of ABC\/2 Method to Determine Infarct Volume and Mismatch Percentage with CT Perfusion"],"prefix":"10.1111","volume":"24","author":[{"given":"Kris F.","family":"French","sequence":"first","affiliation":[{"name":"Department of Neurology University of Utah  Salt Lake City UT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie 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