{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T04:57:11Z","timestamp":1696309031398},"reference-count":8,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,1,16]],"date-time":"2013-01-16T00:00:00Z","timestamp":1358294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>BACKGROUND AND PURPOSE<\/jats:title><jats:p>To describe a patient with relapsing remitting MS who was treated with natalizumab for 36 months. First symptoms of presumptive progressive multifocal leukoencephalopathy (PML) appeared 14 weeks after her last natalizumab infusion.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Neurological examination, MRI and CSF analysis were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The lack of anti\u2010inflammatory treatment response, clinical course, and serial MRI examinations showed lesion development typical for PML on diffusion\u2010weighted and FLAIR MRI. CSF analysis for JC virus was tested negative twice.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>This case represents a presumptive PML after discontinuation of natalizumab treatment\u2014similar to the definition established for PML in HIV patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jon.12010","type":"journal-article","created":{"date-parts":[[2013,1,16]],"date-time":"2013-01-16T19:57:55Z","timestamp":1358366275000},"page":"425-428","source":"Crossref","is-referenced-by-count":3,"title":["Presumptive Progressive Multifocal Leukoencephalopathy in Multiple Sclerosis after Natalizumab Therapy"],"prefix":"10.1111","volume":"24","author":[{"given":"Philipp","family":"Eisele","sequence":"first","affiliation":[{"name":"Department of Neurology Universit\u00e4tsMedizin Mannheim University of Heidelberg  Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristina","family":"Szabo","sequence":"additional","affiliation":[{"name":"Department of Neurology Universit\u00e4tsMedizin Mannheim University of Heidelberg  Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Hornberger","sequence":"additional","affiliation":[{"name":"Department of Neurology Universit\u00e4tsMedizin Mannheim University of Heidelberg  Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Griebe","sequence":"additional","affiliation":[{"name":"Department of Neurology Universit\u00e4tsMedizin Mannheim University of Heidelberg  Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael G.","family":"Hennerici","sequence":"additional","affiliation":[{"name":"Department of Neurology Universit\u00e4tsMedizin Mannheim University of Heidelberg  Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernd C.","family":"Kieseier","sequence":"additional","affiliation":[{"name":"Department of Neurology Heinrich\u2010Heine Universit\u00e4t  D\u00fcsseldorf Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Achim","family":"Gass","sequence":"additional","affiliation":[{"name":"Department of Neurology Universit\u00e4tsMedizin Mannheim University of Heidelberg  Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,1,16]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa054693"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp0906248"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22137"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0810257"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0810316"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A2035"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31823b9b27"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.23676"}],"container-title":["Journal of Neuroimaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjon.12010","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjon.12010","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jon.12010","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T12:08:40Z","timestamp":1696248520000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jon.12010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1,16]]},"references-count":8,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["10.1111\/jon.12010"],"URL":"https:\/\/doi.org\/10.1111\/jon.12010","archive":["Portico"],"relation":{},"ISSN":["1051-2284","1552-6569"],"issn-type":[{"value":"1051-2284","type":"print"},{"value":"1552-6569","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1,16]]}}}