{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T03:18:50Z","timestamp":1790219930301,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,9,3]],"date-time":"2013-09-03T00:00:00Z","timestamp":1378166400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Health and Labor Sciences Research"},{"name":"Ministry of Health, Labour and Welfare of Japan","award":["2008-Nanchi-17"],"award-info":[{"award-number":["2008-Nanchi-17"]}]},{"name":"Strategic Medical Science Research Center"},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science, and Technology of Japan","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>OBJECTIVE<\/jats:title><jats:p>To determine whether voxel\u2010based morphometry of the cerebrospinal fluid (CSF) space can accurately differentiate iNPH from other related neurological disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Nineteen patients with surgically proven iNPH and 24 patients with Alzheimer's disease (AD), 18 patients with Parkinson's disease (PD), and 14 healthy elderlies were examined. Regions of interest (ROIs) in the ventricular\/sylvian (VS) and high convexity\/midline (HCM) areas were used in VBM, and differences in CSF volume within these ROIs among the 4 groups were examined.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The relative CSF volume in the VS\u2010ROI in the iNPH group (.64) was significantly higher than that in the AD, PD, and healthy control groups (.26, .29, and .17, respectively; <jats:italic>P<\/jats:italic> &lt; .001), whereas the relative CSF volume in the HCM\u2010ROI was significantly reduced in the iNPH (.10) than in the other (.17, .16, and .16, respectively) groups (<jats:italic>P<\/jats:italic> &lt; .001). Furthermore, the ratio of the 2 areas (VS\/HCM) was markedly higher in the iNPH (6.87) than in the other (1.65, 1.74, .97, respectively) groups (<jats:italic>P<\/jats:italic> &lt; .001), with sensitivity and specificity of .89 and 1.00, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>The VBM\u2010based CSF space analysis can detect disproportionate changes in CSF space and differentiate iNPH patients from those with AD or PD and healthy elderlies accurately.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jon.12049","type":"journal-article","created":{"date-parts":[[2013,9,3]],"date-time":"2013-09-03T14:47:07Z","timestamp":1378219627000},"page":"359-365","source":"Crossref","is-referenced-by-count":22,"title":["Voxel\u2010Based Morphometry of Disproportionate Cerebrospinal Fluid Space Distribution for the Differential Diagnosis of Idiopathic Normal Pressure 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