{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:30:22Z","timestamp":1792798222884,"version":"4.5.0"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,11,19]],"date-time":"2013-11-19T00:00:00Z","timestamp":1384819200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"name":"the Cross Research Fund of MedicalEngineering of Shanghai Jiaotong University","award":["YG2012MS12"],"award-info":[{"award-number":["YG2012MS12"]}],"id":[{"id":"https:\/\/ror.org\/0220qvk04","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND AND PURPOSE<\/jats:title>\n                    <jats:p>Patients with amnestic mild cognitive impairment (aMCI) are at risk of developing Alzheimer's disease (AD). It is therefore important to identify biomarkers of conversion to AD. This study examined whether the integrity of white matter can predict this conversion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      Magnetic resonance imaging (MRI), diffusion tensor imaging (DTI) and neuropsychological features of aMCI subjects (\n                      <jats:italic>n<\/jats:italic>\n                      = 41) were compared with normal controls (\n                      <jats:italic>n<\/jats:italic>\n                      = 20) for 12\u201036 months.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Compared to controls, 22 aMCI subjects had lower fractional anisotropy (FA) values in the cingulate fasciculus (CF) at baseline, and 19 of those converted to AD during follow\u2010up. Only two of the other 19 aMCI patients converted to AD. Compared to baseline, AD converters showed lower FA values in the anterior frontal lobe, temporal lobe, hippocampus, inferior fronto\u2010occipital fascicles, corpus callosum genu and CF, and higher apparent diffusion coefficient values in the temporal lobe and hippocampus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>Those aMCI subjects with lower than normal FA values in the CF were more likely to convert to AD. The connectivity of the hippocampus and cingulate bundles may be affected in the early stage of AD. Impairment of white matter and fiber bundles was more severe at the AD stage than the aMCI stage.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jon.12061","type":"journal-article","created":{"date-parts":[[2013,11,19]],"date-time":"2013-11-19T11:06:54Z","timestamp":1384859214000},"page":"343-348","source":"Crossref","is-referenced-by-count":24,"title":["Use of Diffusion Tensor Imaging for Evaluating Changes in the Microstructural Integrity of White Matter Over 3 Years in Patients with Amnesic\u2010Type Mild Cognitive Impairment Converting to Alzheimer's Disease"],"prefix":"10.1111","volume":"24","author":[{"given":"Jian\u2010Liang","family":"Fu","sequence":"first","affiliation":[{"name":"Department of Neurology Shanghai Jiaotong University Affiliated Sixth People's Hospital  Shanghai 200233 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Emergency Shanghai Eighth People's Hospital  Shanghai 200235 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Mei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology Shanghai Jiaotong University Affiliated Sixth People's Hospital  Shanghai 200233 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Radiology Shanghai Jiaotong University Affiliated Sixth People's Hospital  Shanghai 200233 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010Bin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiology Shanghai Jiaotong University Affiliated Sixth People's Hospital  Shanghai 200233 P. R. 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