{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:17:40Z","timestamp":1760955460216},"reference-count":9,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,2,19]],"date-time":"2014-02-19T00:00:00Z","timestamp":1392768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Universidad Espiritu Santo - Ecuador","award":["n\/a"],"award-info":[{"award-number":["n\/a"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>BACKGROUND AND PURPOSE<\/jats:title><jats:p>Studies on Whites and Asians have shown contradictory results on the association between an incomplete circle of Willis (CoW) and white matter disease (WMD). We evaluated such relationship in Ecuadorian Mestizos.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Ecuadorian Mestizos aged \u226540 years were evaluated with MRI and MRA. WMD was graded according to the modified Fazekas\u2019 scale, and the CoW was classified as complete or incomplete according to the presence or absence of one A<jats:sub>1<\/jats:sub> segment of the anterior cerebral artery or one or both P<jats:sub>1<\/jats:sub> segments of posterior cerebral arteries.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>A total of 315 persons (mean age 64.7 \u00b1 13.4 years, 56.5% women) were prospectively enrolled over 6 months. MRAs revealed a complete CoW in 65.1%, and MRIs showed WMD in 62.5% of cases. Irrespective of age and sex, incompleteness of the CoW was not associated with a higher prevalence or severity of WMD. In contrast, age was an independent risk factor for the occurrence of WMD.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>In the Ecuadorian Mestizo population, WMD occurrence and severity do not seem to be related to incompleteness of the CoW.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jon.12077","type":"journal-article","created":{"date-parts":[[2014,2,20]],"date-time":"2014-02-20T15:07:54Z","timestamp":1392908874000},"page":"124-126","source":"Crossref","is-referenced-by-count":5,"title":["Variants in the Circle of Willis and White Matter Disease in Ecuadorian Mestizos"],"prefix":"10.1111","volume":"25","author":[{"given":"Oscar H.","family":"Del Brutto","sequence":"first","affiliation":[{"name":"School of Medicine Universidad Esp\u00edritu Santo\u2013Ecuador"},{"name":"Departments of Neurological Sciences Hospital\u2010Cl\u00ednica Kennedy  Guayaquil Ecuador"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julio","family":"Lama","sequence":"additional","affiliation":[{"name":"Department of Imaging Hospital\u2010Cl\u00ednica Kennedy  Guayaquil Ecuador"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,2,19]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-010-9923-7"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijs.12042"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2011.03400.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.64.12.2163-a"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000142041.42491.F4"},{"key":"e_1_2_5_7_1","volume-title":"Annual Projections of the Resident Population by Age, Sex, Race, and Hispanic Origin: Lowest, Middle, Highest, and Zero International Migration Series, 1999 to 2010","author":"US Census Bureau","year":"2000"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000081050"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2002.96.4.0697"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000088063.74250.DB"}],"container-title":["Journal of Neuroimaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjon.12077","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjon.12077","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jon.12077","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T06:17:02Z","timestamp":1696227422000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jon.12077"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,19]]},"references-count":9,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["10.1111\/jon.12077"],"URL":"https:\/\/doi.org\/10.1111\/jon.12077","archive":["Portico"],"relation":{},"ISSN":["1051-2284","1552-6569"],"issn-type":[{"value":"1051-2284","type":"print"},{"value":"1552-6569","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,19]]}}}