{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T18:44:39Z","timestamp":1790361879635,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,3,5]],"date-time":"2014-03-05T00:00:00Z","timestamp":1393977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Posterior cortical atrophy (PCA) is a rare neurodegenerative syndrome with visuospatial deficits. PET studies have identified hypometabolism of the occipital cortex in PCA. There is, however, a huge overlap in clinical presentation and involvement of the occipital cortex between PCA, dementia with Lewy bodies (DLB), and Alzheimer's disease (AD). Syndrome\u2010specific patterns of metabolism have not yet been demonstrated that allow for a reliable differentiation with [F\u201018]\u2010FDG\u2010PET.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>A total of 33 dementia patients (PCA <jats:italic>n<\/jats:italic> = 6, DLB <jats:italic>n<\/jats:italic> = 12, AD <jats:italic>n<\/jats:italic> = 15) who underwent [F\u201018]\u2010FDG\u2010PET imaging and a neuropsychological examination were retrospectively analyzed. Group comparisons of regional cerebral glucose metabolism were calculated with statistical parametric mapping. Extracted clusters were used to evaluate discrimination accuracy by logistic regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>PCA patients showed a syndrome\u2010specific area of hypometabolism in the right lateral temporooccipital cortex. DLB patients showed specific hypometabolism predominantly in the left occipital cortex. Logistic regression based on these two regions correctly separated patients with a sensitivity\/specificity of 83\/93% for PCA, 75\/86% for DLB and 67\/78% for AD. Overall accuracy was 73%.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>[F\u201018]\u2010FDG\u2010PET could reveal syndrome\u2010specific patterns of glucose metabolism in PCA and DLB. Accurate group discrimination in the differential diagnosis of dementia with visuospatial impairment is feasible.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jon.12104","type":"journal-article","created":{"date-parts":[[2014,3,5]],"date-time":"2014-03-05T05:25:10Z","timestamp":1393997110000},"page":"281-288","source":"Crossref","is-referenced-by-count":29,"title":["Syndrome\u2010Specific Patterns of Regional Cerebral Glucose Metabolism in Posterior Cortical Atrophy in Comparison to Dementia with Lewy Bodies and Alzheimer's Disease\u2014A [F\u201018]\u2010Fdg Pet Study"],"prefix":"10.1111","volume":"25","author":[{"given":"Timo S.","family":"Spehl","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Hellwig","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy  Freiburg Germany"},{"name":"Department of Neurology  Freiburg 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