{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T17:32:42Z","timestamp":1770485562066,"version":"3.49.0"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,6,18]],"date-time":"2014-06-18T00:00:00Z","timestamp":1403049600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Department of Neurology, University Medical Center Utrecht"},{"name":"Medical Faculty, University of Technology Dresden, Dresden, Germany"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>BACKGROUND AND PURPOSE<\/jats:title><jats:p>The posterior circulation Acute Stroke Prognosis Early CT Score (pc\u2010APECTS) applied to CT angiography source images (CTA\u2010SI) predicts the functional outcome of patients in the Basilar Artery International Cooperation Study (BASICS). We assessed the diagnostic and prognostic impact of pc\u2010ASPECTS applied to perfusion CT (CTP) in the BASICS registry population.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>We applied pc\u2010ASPECTS to CTA\u2010SI and cerebral blood flow (CBF), cerebral blood volume (CBV), and mean transit time (MTT) parameter maps of BASICS patients with CTA and CTP studies performed. Hypoattenuation on CTA\u2010SI, relative reduction in CBV or CBF, or relative increase in MTT were rated as abnormal.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>CTA and CTP were available in 27\/592 BASICS patients (4.6%). The proportion of patients with any perfusion abnormality was highest for MTT (93%; 95% confidence interval [CI], 76%\u201099%), compared with 78% (58%\u201091%) for CTA\u2010SI and CBF, and 46% (27%\u201067%) for CBV (<jats:italic>P<\/jats:italic> &lt; .001). All 3 patients with a CBV pc\u2010ASPECTS &lt; 8 compared to 6\/23 patients with a CBV pc\u2010ASPECTS \u2265 8 had died at 1 month (RR 3.8; 95% CI, 1.9\u20107.6).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>CTP was performed in a minority of the BASICS registry population. Perfusion disturbances in the posterior circulation were most pronounced on MTT parameter maps. CBV pc\u2010ASPECTS &lt; 8 may indicate patients with high case fatality.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jon.12130","type":"journal-article","created":{"date-parts":[[2014,6,18]],"date-time":"2014-06-18T15:48:49Z","timestamp":1403106529000},"page":"384-389","source":"Crossref","is-referenced-by-count":55,"title":["Diagnostic and Prognostic Impact of pc\u2010ASPECTS Applied to Perfusion CT in the Basilar Artery International Cooperation Study"],"prefix":"10.1111","volume":"25","author":[{"given":"Lars\u2010Peder","family":"Pallesen","sequence":"first","affiliation":[{"name":"Dresden University Stroke Center University of Technology Dresden  Dresden Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Gerber","sequence":"additional","affiliation":[{"name":"Dresden University Stroke Center University of Technology Dresden  Dresden Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Imanuel","family":"Dzialowski","sequence":"additional","affiliation":[{"name":"Dresden University Stroke Center University of Technology Dresden  Dresden Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik J.R.J.","family":"van der Hoeven","sequence":"additional","affiliation":[{"name":"St. Antonius Hospital Nieuwegein  Nieuwegein The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrik","family":"Michel","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire Vaudois  Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Pfefferkorn","sequence":"additional","affiliation":[{"name":"University of Munich Klinikum Grosshadern  Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Ozdoba","sequence":"additional","affiliation":[{"name":"University of Bern  Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. Jaap","family":"Kappelle","sequence":"additional","affiliation":[{"name":"Utrecht Stroke Center  Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baerbel","family":"Wiedemann","sequence":"additional","affiliation":[{"name":"Institute for Medical Informatics and Biometry University of Technology Dresden  Dresden Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrei","family":"Khomenko","sequence":"additional","affiliation":[{"name":"University of Regensburg  Regensburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ale","family":"Algra","sequence":"additional","affiliation":[{"name":"Utrecht Stroke Center  Utrecht The Netherlands"},{"name":"Julius Center for Health Sciences and Primary Care  Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael D.","family":"Hill","sequence":"additional","affiliation":[{"name":"Calgary Stroke Program University of Calgary  Calgary Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruediger","family":"von Kummer","sequence":"additional","affiliation":[{"name":"Dresden University Stroke Center University of Technology Dresden  Dresden Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew M.","family":"Demchuk","sequence":"additional","affiliation":[{"name":"Calgary Stroke Program University of Calgary  Calgary Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wouter J.","family":"Schonewille","sequence":"additional","affiliation":[{"name":"St. Antonius Hospital Nieuwegein  Nieuwegein The Netherlands"},{"name":"Utrecht Stroke Center  Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Volker","family":"Puetz","sequence":"additional","affiliation":[{"name":"Dresden University Stroke Center University of Technology Dresden  Dresden 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