{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T05:17:24Z","timestamp":1790313444284,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,7,15]],"date-time":"2014-07-15T00:00:00Z","timestamp":1405382400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>BACKGROUND AND PURPOSE<\/jats:title><jats:p>Carotid intraplaque hemorrhage leads to plaque progression and ischemic events.<\/jats:p><jats:p>Detection can be accomplished with 3T T1w sequences, but may be limited by false\u2010positive lipid\/necrosis. The purpose of this study was threefold: (1) to determine if magnetization\u2010prepared rapid acquisition with gradient\u2010echo (MPRAGE) detects intraplaque hemorrhage versus lipid\/necrosis; (2) if 3T MPRAGE image quality is retained at 1.5T; and (3) to determine observer agreement.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>MPRAGE positive areas were compared to hemorrhage and lipid\/necrosis areas from 100 carotid endarterectomy slides in 12 subjects using multivariable linear regression. Image quality was determined between 3T and 1.5T in 716 carotid arteries using <jats:italic>t<\/jats:italic>\u2010tests and multivariable linear regression. Kappa analysis was used to determine agreement.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Intraplaque hemorrhage, not lipid\/necrosis, was a significant predictor of MPRAGE positive area before and after adjusting for confounders (slope = .52 vs. .51, <jats:italic>P<\/jats:italic> &lt; .001).<\/jats:p><jats:p>Image quality at 3T was slightly lower than 1.5T (mean 3.87 vs. 4.34, <jats:italic>P<\/jats:italic> &lt; .0001). 3T image quality remained slightly decreased before and after adjusting for confounders (slope = \u2013.46 vs. \u2013.41, <jats:italic>P<\/jats:italic> &lt; .001). Kappa values for inter\u2010\/intraobserver agreement were .807\/.919 at 3T and .803\/.871 at 1.5T.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Carotid MPRAGE detects intraplaque hemorrhage, not lipid\/necrosis. 3T image quality was retained at 1.5T with very good observer agreement.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jon.12146","type":"journal-article","created":{"date-parts":[[2014,7,16]],"date-time":"2014-07-16T03:48:56Z","timestamp":1405482536000},"page":"390-396","source":"Crossref","is-referenced-by-count":34,"title":["Carotid MRI Detection of Intraplaque Hemorrhage at 3T and 1.5T"],"prefix":"10.1111","volume":"25","author":[{"given":"J.","family":"Scott McNally","sequence":"first","affiliation":[{"name":"Utah Center for Advanced Imaging Research Department of Radiology University of Utah School of Medicine  Salt Lake City 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