{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T07:26:03Z","timestamp":1790666763648,"version":"4.1.0"},"reference-count":14,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,9,26]],"date-time":"2014-09-26T00:00:00Z","timestamp":1411689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>BACKGROUND AND PURPOSE<\/jats:title><jats:p>Cerebral vasomotor reserve (VMR) is the capability of cerebral arterioles to change their diameter in response to various stimuli, such hypercapnia. Changes of VMR due to transcranial direct current stimulation (tDCS) have been poorly studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Twenty\u2010five healthy subjects underwent anodal\/cathodal and sham tDCS on right primary motor area. Before and after tDCS, we assessed VMR by Transcranial Color\u2010Coded Sonography (TCCS) calculating trought Breath Holding Index (BHI) and Heart Rate Variability (HRV), in particular after Valsalva manouver.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>A\u2010tDCS decreased VMR and BHI (p &lt; 0.05), whereas C\u2010tDCS increased VMR, and BHI (p &lt; 0.05); Sham doesn't provide statistically significant of both VMR, BHI and HRV (p &gt; 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Our study confirms that tDCS induces a modification of bilateral VMR with a polarity\u2010specific effect; based on this bilateral MFV and BHI modifications, we can speculate an involvement of the SNS in the VMR regulation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jon.12162","type":"journal-article","created":{"date-parts":[[2014,9,26]],"date-time":"2014-09-26T10:01:14Z","timestamp":1411725674000},"page":"571-574","source":"Crossref","is-referenced-by-count":20,"title":["Transcranial Direct Current Stimulation and Cerebral Vasomotor Reserve: A Study in Healthy Subjects"],"prefix":"10.1111","volume":"25","author":[{"given":"Elisa","family":"Giorli","sequence":"first","affiliation":[{"name":"Department of Clinical and Experimental Medicine Pisa University, Medical School  Pisa Italy"},{"name":"Department of Neuroscience Neurology and Clinical Neurophysiology Section University of Siena  Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Tognazzi","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine Pisa University, Medical School  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Briscese","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine Pisa University, Medical School  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tommaso","family":"Bocci","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine Pisa University, Medical School  Pisa Italy"},{"name":"Department of Neuroscience Neurology and Clinical Neurophysiology Section University of Siena  Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Mazzatenta","sequence":"additional","affiliation":[{"name":"CNR Neuroscience Institute  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Priori","sequence":"additional","affiliation":[{"name":"Department of Medical Surgical Pathophysiology and Transplants Fondazione IRCCS \u201cCa\u2019 Granda\u201d Ospedale Maggiore di Milano  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Orlandi","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine Pisa University, Medical School  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Del Sette","sequence":"additional","affiliation":[{"name":"Unit of Neurology, Sant' Andrea Hospital  La Spezia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferdinando","family":"Sartucci","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine Pisa University, Medical School  Pisa Italy"},{"name":"Faculty of Veterinary Medicine, Unit of Sensorial Physiology, Teramo University  Teramo 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