{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T13:50:25Z","timestamp":1772805025231,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,1,15]],"date-time":"2015-01-15T00:00:00Z","timestamp":1421280000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>BACKGROUND AND PURPOSE<\/jats:title><jats:p>Optic neuritis (ON) is an acute episode of inflammation in the visual pathway (VP). It may occur as part of a demyelinating disease, which can affect white matter (WM) throughout the VP. Compensatory cortical adaptations may occur following WM damage to maintain visual integrity. Our aim was to investigate whether resting\u2010state functional MRI (rsfMRI) can detect cortical adaptations following ON attacks and to correlate rsfMRI with diffusion tensor imaging (DTI) of WM within the VP.<\/jats:p><\/jats:sec><jats:sec><jats:title>MATERIALS AND METHODS<\/jats:title><jats:p>Neuromyelitis optica spectrum patients were compared to healthy controls at least 6 months after ON onset. DTI and rsfMRI were performed and post\u2010processed using FSL tools (TBSS for DTI and MELODIC for fMRI).<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Ptients had higher synchronization values than controls in the visual network (3.48 vs. 2.12, <jats:italic>P<\/jats:italic> &lt; .05). A weak trend of correlation was revealed between fMRI and structural analysis by DTI using fractional anisotropy (right side: R = \u2212.36, <jats:italic>P<\/jats:italic> &lt; .08; left side: R = .075, <jats:italic>P<\/jats:italic> &lt; .73).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>The rsfMRI detected cortical reorganization following ON attack, but WM was considerably preserved in the posterior VP.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jon.12191","type":"journal-article","created":{"date-parts":[[2015,1,15]],"date-time":"2015-01-15T13:28:29Z","timestamp":1421328509000},"page":"807-812","source":"Crossref","is-referenced-by-count":14,"title":["Optic Neuritis and the Visual Pathway: Evaluation of Neuromyelitis Optica Spectrum by Resting\u2010State fMRI and Diffusion Tensor MRI"],"prefix":"10.1111","volume":"25","author":[{"given":"Fernanda Cristina Rueda","family":"Lopes","sequence":"first","affiliation":[{"name":"Federal University of Rio de Janeiro Radiology  Rua Presidente Jo\u00e3o Pessoa Niter\u00f3i Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soniza Vieira","family":"Alves\u2010Leon","sequence":"additional","affiliation":[{"name":"Federal University of Rio de Janeiro Neurology  Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose Mauricio","family":"Godoy","sequence":"additional","affiliation":[{"name":"State University of Rio de Janeiro Neurology  Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone","family":"de Souza Batista Scherpenhuijzen","sequence":"additional","affiliation":[{"name":"State University of Rio de Janeiro Neurology  Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leticia","family":"Fezer","sequence":"additional","affiliation":[{"name":"State University of Rio de Janeiro Neurology  Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emerson Leandro","family":"Gasparetto","sequence":"additional","affiliation":[{"name":"Federal University of Rio de Janeiro Radiology  Rua Presidente Jo\u00e3o Pessoa Niter\u00f3i Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,1,15]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000335766.22758.cd"},{"issue":"4","key":"e_1_2_5_3_1","first-page":"452","article-title":"Magnetic resonance diffusion tensor imaging and diffusion tensor tractography of human visual pathway","volume":"5","author":"Zhang Y","year":"2012","journal-title":"Int J Ophthalmol"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2009.107"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A2574"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/265306"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nurt.2007.05.011"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(02)00700-0"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-1331.2002.00399.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.10091433"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22366"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2007.45"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.07.051"},{"key":"e_1_2_5_14_1","unstructured":"AnderssonJLR JenkinsonM SmithS.Non\u2010linear optimisation. FMRIB technical report TR07JA1 fromwww.fmrib.ox.ac.uk\/analysis\/techrep"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.02.024"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1109\/42.796284"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awq058"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2005.1634"},{"issue":"1","key":"e_1_2_5_19_1","first-page":"S39","article-title":"Group comparison of resting\u2010state FMRI data using multi\u2010subject ICA and dual regression","volume":"47","author":"Beckmann CF","year":"2009","journal-title":"NeuroImage"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.03.061"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21823"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.07.030"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-009-0123-z"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20448"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.05.031"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.68.4.441"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.11-8864"}],"container-title":["Journal of Neuroimaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjon.12191","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjon.12191","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jon.12191","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T05:18:17Z","timestamp":1696223897000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jon.12191"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,15]]},"references-count":26,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["10.1111\/jon.12191"],"URL":"https:\/\/doi.org\/10.1111\/jon.12191","archive":["Portico"],"relation":{},"ISSN":["1051-2284","1552-6569"],"issn-type":[{"value":"1051-2284","type":"print"},{"value":"1552-6569","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,15]]}}}