{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T23:48:21Z","timestamp":1769212101005,"version":"3.49.0"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Direct Grant for Research","award":["reference No. 2005.1.082"],"award-info":[{"award-number":["reference No. 2005.1.082"]}]},{"name":"S. H. Ho Cardio-vascular and Stroke Center of the Chinese University of Hong Kong"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>BACKGROUND AND PURPOSE<\/jats:title><jats:p>Increased cerebral blood flow velocity of basilar artery (BA) is common but often neglected. By using digital subtraction angiography (DSA) to detect intracranial large artery stenosis, we performed transcranial Doppler (TCD) to evaluate cerebral hemodynamic changes of stroke patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Acute stroke patients with TCD\u2010detected raised peak systolic velocity (PSV) in BA (\u2265100 cm\/second) were recruited.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Among 91 recruited patients, BA stenosis (&gt;50%) was confirmed by using DSA in 29 patients (32%), among which 20 patients (70.0%) had coexistent internal carotid artery (ICA) and vertebral artery (VA) stenoses. Among patients without BA stenosis (<jats:italic>n<\/jats:italic> = 62, 68%), severe stenosis or occlusion of ICA was evaluated in 22 patients (22\/62, 35.4%) and severe stenosis or occlusion of VA was detected in 22 patients (22\/62, 35.4%). Among the values of PSV (120, 140, 160, and 180 cm\/second) and the stenotic\u2010to\u2010prestenotic ratio (SPR) (1.5, 2.0, 2.5, and 3.0), 160 cm\/second was found to show the highest predictive value (area under the receiver operator characteristic curve: .75, 95% CI: .65\u2010.86), with a sensitivity of .70 and a specificity of .81.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Apart from an intrinsic BA stenosis, high\u2010grade steno\u2010occlusion of ICA or VA may contribute a lot to induce an elevated flow velocity in BA. A higher value of cutoff point may increase the accuracy of diagnosing BA stenosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jon.12245","type":"journal-article","created":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T18:08:50Z","timestamp":1430503730000},"page":"922-926","source":"Crossref","is-referenced-by-count":7,"title":["Significance of Raised Flow Velocity in Basilar Artery in Patients with Acute Ischemic Stroke: Focal Stenosis, Coexistent Stenosis, and Collateral Flow"],"prefix":"10.1111","volume":"25","author":[{"given":"Jingxin","family":"Zhong","sequence":"first","affiliation":[{"name":"Cerebrovascular Disease Center Guangdong Province Traditional Medicine Hospital  Guangzhou Guangdong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang\u2010Yan","family":"Chen","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Therapeutics, Chinese University of Hong Kong Hong Kong Special Administrative Region  Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas Wai Hong","family":"Leung","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Therapeutics, Chinese University of Hong Kong Hong Kong Special Administrative Region  Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aihua","family":"Ou","sequence":"additional","affiliation":[{"name":"Cerebrovascular Disease Center Guangdong Province Traditional Medicine Hospital  Guangzhou Guangdong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaogeng","family":"Shi","sequence":"additional","affiliation":[{"name":"Cerebrovascular Disease Center Guangdong Province Traditional Medicine Hospital  Guangzhou Guangdong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yefeng","family":"Cai","sequence":"additional","affiliation":[{"name":"Cerebrovascular Disease Center Guangdong Province Traditional Medicine Hospital  Guangzhou Guangdong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Huang","sequence":"additional","affiliation":[{"name":"Cerebrovascular Disease Center Guangdong Province Traditional Medicine Hospital  Guangzhou Guangdong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ka Sing","family":"Wong","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Therapeutics, Chinese University of Hong Kong Hong Kong Special Administrative Region  Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,5]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1552-6569.2010.00523.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.31.11.2641"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1552-6569.2002.tb00083.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1999.tb00660.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1179\/1743132813Y.0000000230"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1552-6569.2008.00337.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.09.2624"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1552-6569.2008.00286.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcu.20193"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000121344"},{"key":"e_1_2_6_12_1","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1001\/jama.1968.03140110053011","article-title":"Joint study of extracranial arterial occlusion. II. Arteriography, techniques, sites, and complications","volume":"203","author":"Hass WK","year":"1968","journal-title":"JAMA"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000264427.09191.89"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0967-5868(02)00264-3"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.40.10.1540"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.621235"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199108153250701"},{"key":"e_1_2_6_18_1","first-page":"643","article-title":"A standardized method for measuring intracranial arterial stenosis","volume":"21","author":"Samuels OB","year":"2000","journal-title":"Am J Neuroradiol"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410290302"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.28.8.1595"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.32.7.1552"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22354"}],"container-title":["Journal of Neuroimaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjon.12245","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjon.12245","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jon.12245","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T06:31:58Z","timestamp":1696228318000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jon.12245"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5]]},"references-count":21,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["10.1111\/jon.12245"],"URL":"https:\/\/doi.org\/10.1111\/jon.12245","archive":["Portico"],"relation":{},"ISSN":["1051-2284","1552-6569"],"issn-type":[{"value":"1051-2284","type":"print"},{"value":"1552-6569","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5]]}}}