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The term frontotemporal lobar degeneration (FTLD) is used to describe the proteinopathies associated with clinical FTD. Emerging evidence from network\u2010based neuroimaging studies, such as resting state functional MRI and diffusion tensor MRI studies, have implicated specific large\u2010scale brain networks in the pathogenesis of FTD syndromes, suggesting a new paradigm for explaining the distributed and heterogeneous spreading patterns of pathological proteins in FTLD. In this review, we overview recent research on the study of FTD syndromes as connectivity disorders in symptomatic patients as well as genotype\u2010specific changes in asymptomatic FTD\u2010related gene mutation carriers. 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