{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:18:35Z","timestamp":1753888715704},"reference-count":60,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,5,12]],"date-time":"2016-05-12T00:00:00Z","timestamp":1463011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>BACKGROUP AND PURPOSE<\/jats:title><jats:p>There are limited data regarding the diagnostic yield of transcranial color\u2010coded Doppler (TCCD) in acute encephalitis. We present our preliminary observations of consecutive ultrasound evaluations in 2 patients with acute encephalitis and we review the possible diagnostic role of TCCD in such cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>We describe two cases of acute encephalitis that presented with aphasia and confusion and underwent repeat TCCD evaluation at baseline and after 48 hours in both patients. We also critically review the current literature regarding potential TCCD applications in acute central nervous system infections.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Serial TCCD evaluations revealed the following triad of abnormal findings in both patients: (i) elevated pulsatility index (PI) in the left middle cerebral artery (M1 MCA) at baseline (&gt;1.2), (ii) increased PI in left M1 MCA by &gt;25% in comparison to right M1 MCA, and (iii) decrease in PI in left M1 MCA by &gt;25% at the follow\u2010up evaluation at 48 hours. The decrease in PI in left M1 MCA coincided with symptom improvement in both patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p>The focal transient increase in left M1 MCA PI may be attributed to focally increased intracranial pressure or peripheral vasospasm of distal left MCA branches. Since there are limited reports in the literature concerning TCCD evaluation of patients with central nervous system infections, our preliminary findings require independent confirmation in a larger series of patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jon.12353","type":"journal-article","created":{"date-parts":[[2016,5,12]],"date-time":"2016-05-12T13:19:51Z","timestamp":1463059191000},"page":"377-382","source":"Crossref","is-referenced-by-count":6,"title":["Transcranial Color\u2010Coded Duplex in Acute Encephalitis: Current Status and Future Prospects"],"prefix":"10.1111","volume":"26","author":[{"given":"Odysseas","family":"Kargiotis","sequence":"first","affiliation":[{"name":"Stroke Unit Metropolitan Hospital  Piraeus Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Apostolos","family":"Safouris","sequence":"additional","affiliation":[{"name":"Stroke Unit Metropolitan Hospital  Piraeus Greece"},{"name":"Stroke Unit, Department of Neurology Brugmann University Hospital  Place Van Gehuchten 4 1020 Bruxelles Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgios","family":"Magoufis","sequence":"additional","affiliation":[{"name":"Stroke Unit Metropolitan Hospital  Piraeus Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleftherios","family":"Stamboulis","sequence":"additional","affiliation":[{"name":"Stroke Unit Metropolitan Hospital  Piraeus Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgios","family":"Tsivgoulis","sequence":"additional","affiliation":[{"name":"Second Department of Neurology, \u201cAttikon\u201d Hospital, School of Medicine University of Athens  Athens Greece"},{"name":"Department of Neurology The University of Tennessee Health Science Center  Memphis TN"},{"name":"International Clinical Research Center, Department of Neurology St. Anne's University Hospital in Brno  Brno Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,5,12]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1982.57.6.0769"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-009-0008-7"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A4548"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.7863\/ultra.33.12.2061"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijs.12340"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-132441"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.112.675074"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1552-6569.2011.00595.x"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000016119"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199202273260905"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.27.10.1844"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-7020-4088-7.00094-8"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0035-1564686"},{"key":"e_1_2_4_15_1","first-page":"195","article-title":"Cerebral blood flow measurements of the extracranial carotid and vertebral arteries with Doppler ultrasound in healthy adults","volume":"11","author":"Yazici B Erdogmus B","year":"2005","journal-title":"Diagn Interv Radiol"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000304747.38502.e8"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/00359157740676P113"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/629378"},{"key":"e_1_2_4_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surneu.2003.12.007"},{"key":"e_1_2_4_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/hc6172.099397"},{"key":"e_1_2_4_21_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.1989.8.3.143"},{"key":"e_1_2_4_22_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/616572"},{"key":"e_1_2_4_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.490755"},{"key":"e_1_2_4_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470752883"},{"key":"e_1_2_4_25_1","doi-asserted-by":"publisher","DOI":"10.3109\/08037051.2012.694181"},{"key":"e_1_2_4_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1552-6569.2003.tb00186.x"},{"key":"e_1_2_4_27_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.20.7.899"},{"key":"e_1_2_4_28_1","first-page":"1788","article-title":"Asymmetry of intracranial hemodynamics as an indicator of mass effect in acute intracerebral hemorrhage","volume":"27","author":"Mayer SA","year":"1996","journal-title":"A transcranial Doppler study. Stroke"},{"key":"e_1_2_4_29_1","first-page":"1","article-title":"Evaluation of intracranial pressure gradients by means of transcranial Doppler sonography","volume":"55","author":"Cardoso ER","year":"1992","journal-title":"Acta Neurochir Suppl (Wien)"},{"key":"e_1_2_4_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1993.tb04142.x"},{"key":"e_1_2_4_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/jon.12100"},{"key":"e_1_2_4_32_1","doi-asserted-by":"publisher","DOI":"10.7863\/ultra.33.12.2131"},{"key":"e_1_2_4_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2014.10.015"},{"key":"e_1_2_4_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0929-6646(09)60345-4"},{"key":"e_1_2_4_35_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2003.22.10.1061"},{"key":"e_1_2_4_36_1","doi-asserted-by":"publisher","DOI":"10.4076\/1752-1947-3-7383"},{"key":"e_1_2_4_37_1","first-page":"754","article-title":"Transcranial Doppler ultrasound monitoring of patients with viral infections of the central nervous system","volume":"66","author":"M\u00fcller M","year":"1995","journal-title":"Nervenarzt"},{"key":"e_1_2_4_38_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2013-201813"},{"key":"e_1_2_4_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200004000-00019"},{"key":"e_1_2_4_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-011-1184-3"},{"key":"e_1_2_4_41_1","doi-asserted-by":"publisher","DOI":"10.1080\/02688699550041160"},{"key":"e_1_2_4_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-014-2435-2"},{"key":"e_1_2_4_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-002-0571-6"},{"key":"e_1_2_4_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-007-6263-0"},{"key":"e_1_2_4_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2007.01852.x"},{"key":"e_1_2_4_46_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.26.8.1399"},{"key":"e_1_2_4_47_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc10565"},{"key":"e_1_2_4_48_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.61.1.57"},{"key":"e_1_2_4_49_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000000092"},{"key":"e_1_2_4_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1552-6569.2003.tb00163.x"},{"key":"e_1_2_4_51_1","first-page":"98","article-title":"Time course of cerebral blood flow velocity in central nervous system infections","volume":"50","author":"Haring HP","year":"1993","journal-title":"A transcranial Doppler sonography study. Arch Neurol"},{"key":"e_1_2_4_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/0301-5629(95)02029-2"},{"key":"e_1_2_4_53_1","doi-asserted-by":"publisher","DOI":"10.15274\/NRJ-2014-10037"},{"key":"e_1_2_4_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70134-6"},{"key":"e_1_2_4_55_1","first-page":"1105","article-title":"Pseudomigraine with temporary neurological symptoms and lymphocytic pleocytosis","volume":"120","author":"G\u00f3mez\u2010Aranda F","year":"1997","journal-title":"A report of 50 cases. Brain"},{"key":"e_1_2_4_56_1","first-page":"317685","article-title":"Confusional state in HaNDL syndrome: case report and literature review","volume":"2013","author":"Nelson S.","year":"2013","journal-title":"Case Rep Neurol Med"},{"key":"e_1_2_4_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2011.01884.x"},{"key":"e_1_2_4_58_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.68.1.111"},{"key":"e_1_2_4_59_1","doi-asserted-by":"publisher","DOI":"10.7863\/ultra.15.02016"},{"key":"e_1_2_4_60_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-007-0016-4"},{"key":"e_1_2_4_61_1","doi-asserted-by":"publisher","DOI":"10.5853\/jos.2013.15.2.78"}],"container-title":["Journal of Neuroimaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjon.12353","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjon.12353","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jon.12353","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T16:08:31Z","timestamp":1696262911000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jon.12353"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,12]]},"references-count":60,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["10.1111\/jon.12353"],"URL":"https:\/\/doi.org\/10.1111\/jon.12353","archive":["Portico"],"relation":{},"ISSN":["1051-2284","1552-6569"],"issn-type":[{"value":"1051-2284","type":"print"},{"value":"1552-6569","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,12]]}}}