{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T13:12:52Z","timestamp":1790946772464,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,6,30]],"date-time":"2016-06-30T00:00:00Z","timestamp":1467244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>BACKGROUND AND PURPOSE<\/jats:title><jats:p>Diffusion tensor imaging (DTI) is sensitive to brain microstructural changes. The aims of this DTI study were to map voxelwise the spatial distribution of brain microstructural changes in patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) and to investigate any correlation between DTI\u2010derived indices and extension of T2 hyperintensity.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Eighteen patients with CADASIL and 18 age\u2010, sex\u2010, and education\u2010level\u2010matched healthy controls underwent magnetic resonance imaging at 3 T. Differences in DTI\u2010derived indices (mean diffusivity [MD], fractional anisotropy [FA], axial [AD] and radial [RD] diffusivities, and mode of anisotropy [MO]) of brain white matter (WM) between CADASIL patients and healthy subjects were assessed through tract\u2010based spatial statistics. Then, DTI\u2010derived indices were correlated with the patient's score on the extended Fazekas visual scale of the T2 hyperintensity.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>When compared to healthy controls, CADASIL patients showed extensive symmetric areas of increased MD\/RD and decreased AD\/FA\/MO that involved almost the entire hemispheric cerebral WM (internal and external capsule, WM of the temporal poles, superior and inferior longitudinal fasciculus, inferior frontal\u2010occipital fasciculus, uncinate fasciculus, cingulum, forceps major and minor, corticospinal tracts, and thalamic radiations), thalami, and corpus callosum. Additional areas of increased RD were observed in pons, midbrain, cerebellar peduncles, and cerebellar WM. Only FA was negatively correlated with extended Fazekas visual score.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Our results indicate that brain damage in CADASIL is associated with extensive microstructural changes implying impairment of intra\u2010 and inter\u2010hemispheric cerebral, thalamocortical, and cerebrocerebellar connections. Severity of microstructural changes correlates with extension of T2 hyperintensity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jon.12374","type":"journal-article","created":{"date-parts":[[2016,6,30]],"date-time":"2016-06-30T06:37:04Z","timestamp":1467268624000},"page":"85-91","source":"Crossref","is-referenced-by-count":26,"title":["Diffusion Tensor Imaging to Map Brain Microstructural Changes in CADASIL"],"prefix":"10.1111","volume":"27","author":[{"given":"Mario","family":"Mascalchi","sequence":"first","affiliation":[{"name":"Neuroradiology Unit A. 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