{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:14:22Z","timestamp":1787015662216,"version":"build-2736575974"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,8,19]],"date-time":"2016-08-19T00:00:00Z","timestamp":1471564800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>We detected a novel imaging sign, which consists of a specific imaging pattern of diffuse susceptibility effect, delineating the cortical\u2010subcortical junction on high\u2010resolution susceptibility\u2010weighted images (SWIs). We describe magnetic resonance imaging findings in 10 patients with \u201csusceptibility etching\u201d and possible association with their abnormal coagulation profile.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>MATERIALS\/METHODS<\/jats:title>\n                    <jats:p>A retrospective case series study with a search for cases that demonstrated susceptibility effect at the cortical\u2010subcortical junction on SWI sequences was performed. The patients\u2019 respective coagulation profiles including prothrombin time, partial thromboplastin time, fibrinogen, D\u2010dimer values, and platelet counts were reviewed. In addition, clinical history and neurological deficits were recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>We identified 10 patients with the \u201csusceptibility etching\u201d pattern at the cortical\u2010subcortical junction. All patients were acutely ill and had a significantly elevated D\u2010dimer (4,309 mcg\/L to &gt;10,000 mcg\/L) with variably reduced platelet count. Two patients had reduced fibrinogen and 5 patients had prolonged international normalized ratio. Of the 10 patients, 4 died during hospitalization, within a few days of imaging. Pathology of 1 patient at autopsy demonstrated findings suggestive of a microvascular thrombotic or embolic event without overt parenchymal microhemorrhage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>In this preliminary case series, we describe patients with \u201csusceptibility etching\u201d on SWI who were also found to have profound coagulation impairment. While other comorbities may also contribute to this novel sign, we suggest that a possible etiology may be secondary to microvascular in situ formation of fine thrombi and\/or emboli lodged into an area of vascular caliber reduction and maybe related to thrombotic microangiopathy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jon.12384","type":"journal-article","created":{"date-parts":[[2016,8,19]],"date-time":"2016-08-19T03:56:41Z","timestamp":1471579001000},"page":"43-49","source":"Crossref","is-referenced-by-count":6,"title":["Susceptibility Etching on MRI in Patients with Microangiopathy"],"prefix":"10.1111","volume":"27","author":[{"given":"Jennifer","family":"Chang","sequence":"first","affiliation":[{"name":"Department of Neuroradiology, Massachusetts General Hospital Harvard Medical School  Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keerthi","family":"Arani","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, Massachusetts General Hospital Harvard Medical School  Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheena","family":"Chew","sequence":"additional","affiliation":[{"name":"Department of Neurology, Massachusetts General Hospital Harvard Medical School  Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew P.","family":"Frosch","sequence":"additional","affiliation":[{"name":"Department of Pathology, Massachusetts General Hospital Harvard Medical School  Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Gilberto","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, Massachusetts General Hospital Harvard Medical School  Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noor","family":"Maza","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, Massachusetts General Hospital Harvard Medical School  Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier M.","family":"Romero","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, Massachusetts General Hospital Harvard Medical School  Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,8,19]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A1400"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-007-0316-z"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1754-9485.2010.02208.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-011-6369-2"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2001.060003831.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.emc.2014.04.008"},{"key":"e_1_2_5_8_1","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1182\/blood.V35.1.104.104","article-title":"The production of schistocytes by fibrin strands (a scanning electron microscope study)","volume":"35","author":"Bull BS","year":"1970","journal-title":"Blood"},{"key":"e_1_2_5_9_1","first-page":"245","article-title":"Neuroradiologic aspects of cerebral disseminated intravascular coagulation","volume":"1","author":"Buonanno FS","year":"1980","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.52.6.1285"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A2351"},{"key":"e_1_2_5_12_1","first-page":"489","article-title":"Thrombotic thrombocytopenic purpura: MR findings","volume":"14","author":"Tardy B","year":"1993","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1552-6569.2007.00091.x"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPO64IWNLYCVVB"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/2052-0492-2-15"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2009.07600.x"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19960415)77:8<1551::AID-CNCR19>3.0.CO;2-Z"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A1355"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000199847.96188.12"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.5853\/jos.2015.17.1.17"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1552-6569.2010.00516.x"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-011-9534-7"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1552-6569.2012.00723.x"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001227"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201411-2118LE"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A2886"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00062-014-0293-7"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2015.12.025"}],"container-title":["Journal of Neuroimaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjon.12384","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjon.12384","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jon.12384","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T09:01:56Z","timestamp":1695718916000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jon.12384"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,19]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["10.1111\/jon.12384"],"URL":"https:\/\/doi.org\/10.1111\/jon.12384","archive":["Portico"],"relation":{},"ISSN":["1051-2284","1552-6569"],"issn-type":[{"value":"1051-2284","type":"print"},{"value":"1552-6569","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,19]]}}}