{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:56:18Z","timestamp":1760028978700},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,11,13]],"date-time":"2016-11-13T00:00:00Z","timestamp":1478995200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>BACKGROUND AND PURPOSE<\/jats:title><jats:p>Transorbital sonography (TOS) is a promising tool to support the clinical diagnosis of optic neuritis (ON) by showing thickening of optic nerve. In this study, we aimed to define its specific role in follow\u2010up of ON patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>We measured ultrasonography parameters and visual acuity (VA) at presentation and after 1 year in 45 patients with newly diagnosed ON. Two vascular sonographers used B\u2010mode TOS to evaluate mean optic nerve diameter (OND) and optic nerve sheath diameter (ONSD).<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Median ONSD values were significantly thicker in patients with ON in the affected eye (6.4 mm, interquartile range [IQR]: 6.0\u20106.9) at presentation compared with the nonaffected side (5.7 mm; IQR: 5.2\u20106.1) (<jats:italic>P<\/jats:italic> &lt; .001). The median OND was not significantly thicker at presentation in the affected eye (3.0 mm; IQR: 2.9\u20103.4) compared with the fellow eye (2.9 mm; IQR: 2.8\u20103.2) (<jats:italic>P<\/jats:italic> = .09). Logarithmic VA was significantly compromised at presentation in the affected eye (.16; IQR: .00\u2013.55) compared with fellow eye (.00; IQR: .00\u2013.00) (<jats:italic>P<\/jats:italic> &lt; .001). After 1 year, no significant difference (<jats:italic>P<\/jats:italic> \u2265 .05) was found between ONSD or OND of the affected side compared with the nonaffected side. VA improved in most of the patients but remained significantly impaired in affected eye after 1 year.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>TOS is a useful tool to support diagnosis of ON. This technique seems to have less value to evaluate atrophy of the optic nerve after 12 months.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jon.12405","type":"journal-article","created":{"date-parts":[[2016,11,15]],"date-time":"2016-11-15T06:03:42Z","timestamp":1479189822000},"page":"92-96","source":"Crossref","is-referenced-by-count":9,"title":["Transorbital Sonography and Visual Outcome for the Diagnosis and Monitoring of Optic Neuritis"],"prefix":"10.1111","volume":"27","author":[{"given":"Piergiorgio","family":"Lochner","sequence":"first","affiliation":[{"name":"Department of Neurology Saarland University Medical Center  Homburg Germany"},{"name":"Department of Translational Medicine, Section of Neurology University of Piemonte Orientale \u2018\u2018A. Avogadro\u2019\u2019  Novara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurizio A.","family":"Leone","sequence":"additional","affiliation":[{"name":"SC Neurologia, Dept of Medical Sciences IRCCS \u201cCasa Sollievo della Sofferenza\u201d  San Giovanni Rotondo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus","family":"Fassbender","sequence":"additional","affiliation":[{"name":"Department of Neurology Saarland University Medical Center  Homburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Cantello","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine, Section of Neurology University of Piemonte Orientale \u2018\u2018A. Avogadro\u2019\u2019  Novara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenzo","family":"Coppo","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine, Section of Neurology University of Piemonte Orientale \u2018\u2018A. Avogadro\u2019\u2019  Novara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raffaele","family":"Nardone","sequence":"additional","affiliation":[{"name":"Department of Neurology, Christian Doppler Klinik Paracelsus Medical University  Salzburg Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianni","family":"Zorzi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Orthoptic Service Hospital of Merano  Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Lesmeister","sequence":"additional","affiliation":[{"name":"Department of Neurology Saarland University Medical Center  Homburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristoforo","family":"Comi","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine, Section of Neurology University of Piemonte Orientale \u2018\u2018A. Avogadro\u2019\u2019  Novara Italy"},{"name":"Interdisciplinary Research Center of Autoimmune Diseases  Novara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Brigo","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Biomedicine and Movement. Section of Clinical Neurology University of Verona  Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,11,13]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70259-X"},{"key":"e_1_2_5_3_1","first-page":"217802","article-title":"The diagnostic and prognostic value of neurofilament heavy chain levels in immune\u2010mediated optic neuropathies","volume":"2012","author":"Petzold A","year":"2012","journal-title":"Mult Scler Int"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-004-1308-x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)11919-2"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2015.05.005"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A4051"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1552-6569.2012.00758.x"},{"key":"e_1_2_5_9_1","first-page":"587","article-title":"Transorbital echography for assessment of optical nerve atrophy in demyelinating diseases: a pilot study","volume":"54","author":"Fern\u00e1ndez\u2010Dom\u00ednguez J","year":"2012","journal-title":"Rev Neurol"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1991.01080120057025"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1552-6569.2010.00546.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.1995.113"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/acem.12206"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.3928\/1081-597X-19970701-16"},{"key":"e_1_2_5_15_1","first-page":"1","article-title":"Visual acuity measurement standard (Consilium Ophthalmologicum Universale 1984)","author":"Colenbrander A.","year":"1988","journal-title":"Italian J Opht"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0929-8266(02)00036-8"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40477-014-0144-z"},{"key":"e_1_2_5_18_1","first-page":"2437","article-title":"The pathophysiology of acute optic neuritis","volume":"114","author":"Youl BD","year":"1991","journal-title":"An association of gadolinium leakage with clinical and electrophysiological deficits. 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