{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T06:58:45Z","timestamp":1778223525901,"version":"3.51.4"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,10,6]],"date-time":"2017-10-06T00:00:00Z","timestamp":1507248000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>BACKGROUND AND PURPOSE<\/jats:title><jats:p>Nerves and nerve ganglions are supplied by segmental arteries and the vasa nervorum, but the intra\u2010arterial route has not been used for diagnostic or therapeutic purposes. We present the results of intra\u2010arterial delivery of medication for modulating trigeminal nerve ganglion function in patients with refractory trigeminal neuralgia.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>We administered intra\u2010arterial lidocaine in doses up to 50 mg in the middle meningeal artery territory adjacent to the arterial branch that supplies the trigeminal nerve ganglion. We performed electrophysiologic monitoring to serially assess the latency and amplitude of R1 and R2 responses in the blink reflex before and concurrent with each incremental dose of lidocaine. Clinical outcome assessment included a 10\u2010point numeric rating, 4\u2010point severity grading, and the pain\u2010free time interval pre\u2010 and post\u2010treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Intra\u2010arterial lidocaine was administered to three patients with trigeminal neuralgia (35\u2010year\u2010old woman, 57\u2010year\u2010old man, and 34\u2010year\u2010old woman). In all patients, there was a latency prolongation and amplitude reduction of R1 or R2 responses or both which was evident after 5\u201010 mg of lidocaine administration; a more pronounced effect was seen with increasing doses. The second and third patients reported improvement in pain severity on all scales with pain\u2010free intervals of 5 and 3 days, respectively. There was improvement in facial hyperalgesia in all three patients in all dermatomes. All three patients\u2019 symptoms had returned to baseline severity 1 month later.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>We found that modulation of trigeminal nerve activity via the intra\u2010arterial route is possible based on consistent intraprocedural electrophysiologic suppression and short\u2010term clinical improvement in patients with refractory trigeminal neuralgia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jon.12476","type":"journal-article","created":{"date-parts":[[2017,10,6]],"date-time":"2017-10-06T11:52:42Z","timestamp":1507290762000},"page":"79-85","source":"Crossref","is-referenced-by-count":11,"title":["Intra\u2010arterial Modulation of the Trigeminal Nerve Ganglion in Patients with Refractory Trigeminal Neuralgia"],"prefix":"10.1111","volume":"28","author":[{"given":"Adnan I.","family":"Qureshi","sequence":"first","affiliation":[{"name":"Zeenat Qureshi Stroke Institute  St Cloud MN"},{"name":"University of Illinois and Mercyhealth  Rockford IL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5110-2806","authenticated-orcid":false,"given":"Muhammad A.","family":"Saleem","sequence":"additional","affiliation":[{"name":"Zeenat Qureshi Stroke Institute  St Cloud MN"},{"name":"University of Illinois and Mercyhealth  Rockford IL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vikram","family":"Jadhav","sequence":"additional","affiliation":[{"name":"Zeenat Qureshi Stroke Institute  St Cloud MN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shawn S.","family":"Wallery","sequence":"additional","affiliation":[{"name":"University of Illinois and Mercyhealth  Rockford IL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faisal","family":"Raja","sequence":"additional","affiliation":[{"name":"University of Illinois and Mercyhealth  Rockford IL"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,10,6]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/124.12.2347"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nec.2017.02.009"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.3171\/2010.6.JNS10142"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2017.04.085"},{"key":"e_1_2_5_6_1","first-page":"E411","article-title":"Ultrasound\u2010guided pulsed radiofrequency application via the pterygopalatine Fossa: a practical approach to treat refractory trigeminal neuralgia","volume":"18","author":"Nader A","year":"2015","journal-title":"Pain Physician"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2005.01.033"},{"key":"e_1_2_5_8_1","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.wneu.2016.10.028","article-title":"Comparison of percutaneous retrogasserian balloon compression and gamma knife radiosurgery for the treatment of trigeminal neuralgia in multiple sclerosis","volume":"97","author":"Alvarez\u2010Pinzon AM","year":"2017","journal-title":"World Neurosurg"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2017.07.132"},{"key":"e_1_2_5_10_1","article-title":"Imaging of the vasa nervorum using contrast\u2010enhanced ultrasound","author":"Qureshi AI","journal-title":"J Neuroimaging"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)15697-3"},{"key":"e_1_2_5_12_1","first-page":"69","article-title":"Effect of intra\u2010arterial injection of lidocaine and methyl\u2010prednisolone into middle meningeal artery on intractable headaches","volume":"7","author":"Qureshi AI","year":"2014","journal-title":"J Vasc Interv Neurol"},{"key":"e_1_2_5_13_1","unstructured":"International Headache Society.Trigeminal neuralgia. 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