{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T11:18:16Z","timestamp":1764587896123,"version":"3.37.3"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,12,7]],"date-time":"2017-12-07T00:00:00Z","timestamp":1512604800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP15K09837"],"award-info":[{"award-number":["JP15K09837"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>BACKGROUND AND PURPOSE<\/jats:title><jats:p>Acetazolamide reactivity on <jats:sup>123<\/jats:sup>I\u2010IMP SPECT is used to detect misery perfusion due to intracranial atherosclerosis. Noninvasive fractional flow assessed by signal intensity ratio (SIR) on time of flight\u2010magnetic resonance angiography (TOF\u2010MRA) might offer a feasible alternative to identify high\u2010risk intracranial stenosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Data from consecutive patients with unilateral middle cerebral artery (MCA) stenosis who underwent both TOF\u2010MRA and acetazolamide reactivity on <jats:sup>123<\/jats:sup>I\u2010IMP SPECT were retrospectively analyzed. Signal intensity was measured in the background and on the MCA proximal and distal to the stenotic lesion on TOF\u2010MRA. Mean cerebral blood flow (CBF) at rest and cerebrovascular reactivity were measured in the target MCA territory. CBF patterns of the MCA were divided into three groups (Powers\u2019 stage 0\u2010II).<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>A total of 56 sets of diagnostic imaging in 33 patients were assessed. Four CBF patterns were stage II in four MCA territories, stage I in 31, and stage 0 in 21. Median SIR of the MCA was .53 (interquartile range .46\u2010.69) for stage II, .78 (.63\u2010.90) for stage I, and .91 (.85\u2010.95) for stage 0. The optimal cutoff for SIR obtained from receiver operating characteristic curve analysis to predict stage II was &lt; .56.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>In patients with unilateral MCA stenosis, decreased SIR was correlated with misery perfusion, providing a simpler, widely available predictor of high\u2010risk intracranial stenosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jon.12489","type":"journal-article","created":{"date-parts":[[2017,12,7]],"date-time":"2017-12-07T10:34:52Z","timestamp":1512642892000},"page":"206-211","source":"Crossref","is-referenced-by-count":11,"title":["Decreased Signal Intensity Ratio on MRA Reflects Misery Perfusion on SPECT in Patients with Intracranial Stenosis"],"prefix":"10.1111","volume":"28","author":[{"given":"Masatomo","family":"Miura","sequence":"first","affiliation":[{"name":"Department of Neurology Graduate School of Medical Sciences Kumamoto University  Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3547-1307","authenticated-orcid":false,"given":"Makoto","family":"Nakajima","sequence":"additional","affiliation":[{"name":"Department of Neurology Graduate School of Medical Sciences Kumamoto University  Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiko","family":"Fujimoto","sequence":"additional","affiliation":[{"name":"Department of Neurology Graduate School of Medical Sciences Kumamoto University  Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinya","family":"Shiraishi","sequence":"additional","affiliation":[{"name":"Department of Radiology Graduate School of Medical Sciences Kumamoto University  Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David S.","family":"Liebeskind","sequence":"additional","affiliation":[{"name":"Department of Neurology Neurovascular Imaging Research Core 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