{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T20:54:56Z","timestamp":1785790496895,"version":"3.56.0"},"reference-count":65,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,10,16]],"date-time":"2018-10-16T00:00:00Z","timestamp":1539648000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["KO8NS096115"],"award-info":[{"award-number":["KO8NS096115"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RO1HD070996"],"award-info":[{"award-number":["RO1HD070996"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RO1HD086058"],"award-info":[{"award-number":["RO1HD086058"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UL1TR001079"],"award-info":[{"award-number":["UL1TR001079"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012304","name":"School of Medicine, Johns Hopkins University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012304","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>BACKGROUND AND PURPOSE<\/jats:title><jats:p>Neonatal hypoxic\u2010ischemic injury of the brain and resultant encephalopathy (HIE) leads to major developmental impairments by school age. Conventional\/anatomical MRI often fails to detect hippocampal injury in mild cases. We hypothesize that diffusion tensor imaging (DTI) has greater sensitivity for identifying subtle hippocampal injury.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>We retrospectively analyzed DTI data collected from a cohort of neonates with HIE and controls. Conventional MRI sequences were classified qualitatively according to severity using a modified Barkovich scale. Using multivariate linear regression, we compared hippocampal DTI scalars of HIE patients and controls. Spearman correlation was used to test the association of DTI scalars in the hippocampal and thalamic regions. A multiple regression analysis tested the association of the DTI scalars with short\u2010term outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Fifty\u2010five neonates with HIE (42% males) and 13 controls (54% males) were included. Hippocampal DTI scalars were similar between HIE and control groups, even when restricting the HIE group to those with moderate\u2010to\u2010severe injury (8 subjects). DTI scalars of the thalamus were significantly lower in the moderate\u2010to\u2010severely affected patients compared to controls (right fractional anisotropy [FA] .148 vs. .182, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.01; left FA .147 vs. .181, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.03). Hippocampal and thalamic DTI scalars were correlated (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). Hippocampal DTI scalars were not associated with short\u2010term outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Quantitative DTI analysis of the hippocampus in neonates following HIE is a feasible technique to examine neuronal injury. Although DTI scalars were useful in identifying thalamic injury in our cohort, hippocampal DTI analysis did not provide additional information regarding hippocampal injury following HIE.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jon.12572","type":"journal-article","created":{"date-parts":[[2018,10,16]],"date-time":"2018-10-16T12:54:45Z","timestamp":1539694485000},"page":"252-259","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["The Role of Diffusion Tensor Imaging in Detecting Hippocampal Injury Following Neonatal Hypoxic\u2010Ischemic Encephalopathy"],"prefix":"10.1111","volume":"29","author":[{"given":"Jacqueline","family":"Salas","sequence":"first","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, The Johns Hopkins University School of Medicine The Charlotte R. 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Morgan Department of Radiology and Radiological Science The Johns Hopkins University School of Medicine  Baltimore MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn A.","family":"Carson","sequence":"additional","affiliation":[{"name":"Department of Epidemiology The Johns Hopkins Bloomberg School of Public Health  Baltimore MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raul","family":"Chavez\u2010Valdez","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, The Johns Hopkins University School of Medicine The Charlotte R. Bloomberg Children's Center  Baltimore MD"},{"name":"Neuro\u2010Intensive Care Nursery Group The Johns Hopkins School of Medicine  Baltimore MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera Joanna","family":"Burton","sequence":"additional","affiliation":[{"name":"Neuro\u2010Intensive Care Nursery Group The Johns Hopkins School of Medicine  Baltimore MD"},{"name":"Department of Neurology and Developmental Medicine Kennedy Krieger Institute  Baltimore MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl E.","family":"Stafstrom","sequence":"additional","affiliation":[{"name":"Neuro\u2010Intensive Care Nursery Group The Johns Hopkins School of Medicine  Baltimore MD"},{"name":"Division of Pediatric Neurology, Department of Neurology The Johns Hopkins School of Medicine  Baltimore MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frances J.","family":"Northington","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, The Johns Hopkins University School of Medicine The Charlotte R. 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