{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T14:22:01Z","timestamp":1790518921505,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,11,20]],"date-time":"2018-11-20T00:00:00Z","timestamp":1542672000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"DUNN research foundation to KMH"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>BACKGROUND AND PURPOSE<\/jats:title><jats:p>Ventricular enlargement in elderly raises a challenging differential diagnosis to physicians. While Alzheimer's disease is the most common form of dementia, idiopathic normal pressure hydrocephalus (iNPH) constitutes a potentially reversible syndrome. iNPH has a unique pathophysiology pertaining to cerebrospinal fluid (CSF) dynamics and periventricular white matter. We aimed to determine the effects of iNPH on periventricular white matter bundles and to further characterize its ventricular and sulcal CSF distribution by using diffusion tensor tractography (DTT) and CSF volumetrics on high resolution T1\u2010weighted magnetic resonance imaging data.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Deterministic DTT and validated volumetric parcellation were performed on 20 healthy elderly, 13 Alzheimer's disease (AD), and 9 iNPH patients. The superior thalamic radiation, corticospinal tract, and dentatorubrothalamic tract were traced and quantified using DTI studio software. Cloud\u2010based volumetric parcellation was also performed on 138 healthy subjects across the lifespan, 13 AD, and 9 iNPH\u2010patients. Ventricular and sulcal CSF volumes in the three groups were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Combining increased mean diffusivity of the superior thalamic radiation with ventricular volume resulted in clear separation of iNPH from the AD and age\u2010matched healthy subject groups. Additionally, ventricular to sulcal CSF ratio, utilizing fully automated methods, was significantly greater in the iNPH patients compared to AD and healthy age\u2010matched controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Combined microstructural (DTT) and macrostructural (ventricular volume) changes is a promising radiological approach in studying ventriculomegaly. Automated estimation of the disproportionate ventricular and sulcal CSF ratio in patients presenting with ventriculomegaly may be important as radiologic markers in differentiating iNPH from other causes of ventriculomegaly.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jon.12581","type":"journal-article","created":{"date-parts":[[2018,11,21]],"date-time":"2018-11-21T03:02:04Z","timestamp":1542769324000},"page":"242-251","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Diffusion Tensor Imaging of the Superior Thalamic Radiation and Cerebrospinal Fluid Distribution in Idiopathic Normal Pressure Hydrocephalus"],"prefix":"10.1111","volume":"29","author":[{"given":"Kyan","family":"Younes","sequence":"first","affiliation":[{"name":"Department of Neurology, McGovern Medical School University of Texas Health Science Center (UTHSC)  Houston TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khader M.","family":"Hasan","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Imaging McGovern Medical School University of Texas Health Science Center (UTHSC)  Houston TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arash","family":"Kamali","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Imaging McGovern Medical School University of Texas Health Science Center (UTHSC)  Houston TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine E.","family":"McGough","sequence":"additional","affiliation":[{"name":"Department of Neurology, McGovern Medical School University of Texas Health Science Center (UTHSC)  Houston TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zafer","family":"Keser","sequence":"additional","affiliation":[{"name":"Department of Neurology, McGovern Medical School University of Texas Health Science Center (UTHSC)  Houston TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Hasan","sequence":"additional","affiliation":[{"name":"Department of Neurology, McGovern Medical School University of Texas Health Science Center (UTHSC)  Houston TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"Melicher","sequence":"additional","affiliation":[{"name":"Department of Psychiatry McGovern Medical School University of Texas Health Science Center (UTHSC)  Houston TX."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larry A.","family":"Kramer","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Imaging McGovern Medical School University of Texas Health Science Center (UTHSC)  Houston TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul E.","family":"Schulz","sequence":"additional","affiliation":[{"name":"Department of Neurology, McGovern Medical School University of Texas Health Science Center (UTHSC)  Houston TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Alzheimer's Disease Neuroimaging Initiative Researchers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,11,20]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1608808"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.2176\/nmc.52.775"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(65)90016-X"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000168185.29659.C5"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-8454-7-18"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2010.12.008"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.3171\/2015.2.JNS142318"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2002.97.6.1271"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(03)00487-3"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X18760974"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awx191"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A4124"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2014.00266"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awn146"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.3171\/2009.7.JNS09550"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10143-014-0584-0"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.3171\/2016.6.FOCUS16192"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnana.2015.00041"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002349900241"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1212\/CPJ.0b013e3182a78f6b"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12987-018-0090-9"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2010.10.008"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517-6161.1995.tb02031.x"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1109\/MCSE.2016.93"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.02.049"},{"key":"e_1_2_5_27_1","first-page":"178","volume-title":"Neuroanatomy: an atlas of structures, sections, and systems 8th edition","author":"Haines","year":"2008"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-011-6038-5"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A2570"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1177\/0284185113502334"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000367801.35654.EC"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0181624"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/3-211-30714-1_72"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/2045-8118-9-20"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2017.03.003"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20147"}],"container-title":["Journal of Neuroimaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjon.12581","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jon.12581","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T08:59:58Z","timestamp":1694681998000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jon.12581"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,20]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["10.1111\/jon.12581"],"URL":"https:\/\/doi.org\/10.1111\/jon.12581","archive":["Portico"],"relation":{},"ISSN":["1051-2284","1552-6569"],"issn-type":[{"value":"1051-2284","type":"print"},{"value":"1552-6569","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,20]]},"assertion":[{"value":"2018-05-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}