{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T07:55:33Z","timestamp":1722930933066},"reference-count":46,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,11,23]],"date-time":"2018-11-23T00:00:00Z","timestamp":1542931200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003986","name":"Jacobs Foundation","doi-asserted-by":"publisher","award":["JRF 2016\u20132018"],"award-info":[{"award-number":["JRF 2016\u20132018"]}],"id":[{"id":"10.13039\/501100003986","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011102","name":"Seventh Framework Programme","doi-asserted-by":"publisher","award":["602461"],"award-info":[{"award-number":["602461"]}],"id":[{"id":"10.13039\/100011102","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>BACKGROUND AND PURPOSE<\/jats:title><jats:p>In hyperglycemic patients, who succumbed to septic shock, an increased rate of apoptosis of microglial cells and damaged neurons of the hippocampus were found. However, the influence of perioperative glucose levels on hippocampal brain structures has not yet been investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>As part of the ongoing BIOCOG project, a subgroup of <jats:italic>N<\/jats:italic>\u00a0=\u00a065 elderly nondemented patients were analyzed who underwent elective surgery of \u226560\u00a0minutes. In these patients, at least one intraoperative blood glucose (BG) measurement was available from the medical charts. Intraoperative glucose maximum was determined in each patient. Preoperatively and at 3 months follow\u2010up, structural neuroimaging was performed with T1\u2010weighted magnetization prepared rapid gradient\u2010echo sequence (MP\u2010Rage) and a dedicated high\u2010resolution hippocampus magnetic resonance imaging (MRI). The MRI scans were analyzed to assess pre\u2010 or postoperative volume changes of the hippocampus as a whole and hippocampal subfields. We also assessed changes of frontal lobe volume and cortical thickness.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Overall, 173 intraoperative BG levels were obtained in 65 patients (median 2 per patient). A total of 18 patients showed intraoperative hyperglycemia (glucose maximum\u00a0\u2265150 mg\/dL). Controlling for age and diabetes status, no significant impact of intraoperative hyperglycemia was found on the pre\u2013post volume change of the hippocampus as a whole, hippocampal subfields, frontal lobe, and frontal cortical thickness.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>This study found no effect of intraoperative hyperglycemia on postoperative brain structures and volumes including volumes of hippocampus and hippocampal subfields, frontal lobe, and frontal cortical thickness. Further studies investigating the impact of intraoperatively elevated glucose levels should consider a tighter or even continuous glycemic measurement and the determination of central microglial activation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jon.12583","type":"journal-article","created":{"date-parts":[[2018,11,23]],"date-time":"2018-11-23T07:21:16Z","timestamp":1542957676000},"page":"260-267","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Impact of Intraoperative Hyperglycemia on Brain Structures and Volumes"],"prefix":"10.1111","volume":"29","author":[{"given":"Gunnar","family":"Lachmann","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Operative Intensive Care Medicine (CCM, CVK) Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin  Berlin Germany"},{"name":"Berlin Institute of Health (BIH)  Berlin 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