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Different paradigms elicit activations of different components of the language network. The aim of this study is to optimize fMRI clinical usage by comparing the effectiveness of three language tasks for language lateralization and localization in a large group of patients with brain lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>We analyzed fMRI data from a sequential retrospective cohort of 51 patients with brain lesions who underwent presurgical fMRI language mapping. We compared the effectiveness of three language tasks (Antonym Generation, Sentence Completion (SC), and Auditory Naming) for lateralizing language function and for activating cortex within patient\u2010specific regions\u2010of\u2010interest representing eloquent language areas, and assessed the degree of spatial overlap of the areas of activation elicited by each task.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The tasks were similarly effective for lateralizing language within the anterior language areas. The SC task produced higher laterality indices within the posterior language areas and had a significantly higher agreement with the clinical report. Dice coefficients between the task pairs were in the range of .351\u2010.458, confirming substantial variation in the components of the language network activated by each task.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>SC task consistently produced large activations within the dominant hemisphere and was more effective for lateralizing language within the posterior language areas. The low degree of spatial overlap among the tasks strongly supports the practice of using a battery of tasks to help the surgeon to avoid eloquent language areas.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jon.12597","type":"journal-article","created":{"date-parts":[[2019,1,16]],"date-time":"2019-01-16T10:58:43Z","timestamp":1547636323000},"page":"348-356","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Functional MRI Task Comparison for Language Mapping in Neurosurgical Patients"],"prefix":"10.1111","volume":"29","author":[{"given":"Prashin","family":"Unadkat","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Brigham and Women's Hospital Harvard Medical School  Boston MA"},{"name":"Department of Radiology, Brigham and Women's Hospital Harvard Medical School  Boston 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