{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T13:27:13Z","timestamp":1775914033066,"version":"3.50.1"},"reference-count":43,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T00:00:00Z","timestamp":1557100800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["2K12NS001696\u201011A"],"award-info":[{"award-number":["2K12NS001696\u201011A"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND AND PURPOSE<\/jats:title>\n                    <jats:p>Tuberous sclerosis complex (TSC) is a rare, genetic disease that is associated with multiple manifestations including epilepsy and autism. Self\u2010injurious behaviors (SIBs) also occur in a subset of patients. This study used diffusion tensor imaging (DTI) in children with TSC for quantitative and volumetric analysis of brain regions that have been associated with SIB in other genetic conditions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We used DTI to compare 6 children with TSC\u2010associated SIB and 10 children with TSC without SIB. Atlas\u2010based analysis of DTI data and calculation of number of voxels; fractional anisotropy (FA); and mean, axial, and radial diffusivity were performed for multiple regions; DTI measures were summarized using medians and interquartile ranges and were compared using Wilcoxon rank sum tests and false discovery rates (FDRs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Analysis showed that children with TSC and SIB had reduced numbers of voxels (median) in the bilateral globus pallidus (right: 218 vs. 260,\n                      <jats:italic>P<\/jats:italic>\n                      = .008, FDR = .18; left: 222 vs. 274,\n                      <jats:italic>P<\/jats:italic>\n                      = .002, FDR = .12) and caudate nucleus (right: 712 vs. 896,\n                      <jats:italic>P<\/jats:italic>\n                      = .01, FDR = .26; left: 702 vs. 921,\n                      <jats:italic>P<\/jats:italic>\n                      = .03, FDR = .44) and reduced FA in the bilateral globus pallidus (right: .233 vs. .272,\n                      <jats:italic>P<\/jats:italic>\n                      = .003, FDR = .12; left: .223 vs. .247,\n                      <jats:italic>P<\/jats:italic>\n                      = .004, FDR = .12) and left caudate nucleus (.162 vs. .186,\n                      <jats:italic>P<\/jats:italic>\n                      = .03, FDR = .39) versus children without SIB. No other statistically significant differences were found.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>These data support a correlation between lower volumes of the globus pallidus and caudate with SIB in children with TSC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jon.12628","type":"journal-article","created":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T15:01:25Z","timestamp":1557154885000},"page":"506-511","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Characterization of the Basal Ganglia Using Diffusion Tensor Imaging in Children with Self\u2010Injurious Behavior and Tuberous Sclerosis Complex"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6903-743X","authenticated-orcid":false,"given":"Tanjala T.","family":"Gipson","sequence":"first","affiliation":[{"name":"Department of Pediatrics University of Tennessee Health Sciences Center  Memphis TN"},{"name":"Le Bonheur Children's Hospital and Boling Center for Developmental Disabilities  Memphis TN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Poretti","sequence":"additional","affiliation":[{"name":"Division of Pediatric Radiology and Pediatric Neuroradiology, Department of Radiology and Radiological Sciences Johns Hopkins University School of Medicine  Baltimore MD"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah A.","family":"Kelley","sequence":"additional","affiliation":[{"name":"Departments of Neurology and Pediatrics Johns Hopkins University School of Medicine  Baltimore MD"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathryn A.","family":"Carson","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Johns Hopkins Bloomberg 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