{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T07:14:26Z","timestamp":1792134866664,"version":"4.4.0"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,5,20]],"date-time":"2019-05-20T00:00:00Z","timestamp":1558310400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND AND PURPOSE<\/jats:title>\n                    <jats:p>Meningiomas are the most common primary intracranial tumors, typically treated with surgery and adjuvant radiation in cases of subtotal resection and\/or higher histopathologic grade. Contrast\u2010enhanced magnetic resonance imaging (MRI) is the gold standard for postoperative assessment and adjuvant treatment planning. However, MRI can have limited accuracy particularly in the presence of posttreatment change. [68Ga]\u2010DOTATATE is a Positron Emission Tomography (PET) radiotracer targeting somatostatin receptor 2A (SSTR2A). SSTR2A is a reliable biomarker of meningiomas. We report a consecutive case series of 20 patients evaluated with [68Ga]\u2010DOTATATE PET\/MRI, propose a novel approach to quantitative analysis, and discuss clinical implications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We present a consecutive case series of 20 patients with clinically suspected or pathology\u2010proven meningioma evaluated between July 2018 and February 2019. [68Ga]\u2010DOTATATE PET\/MRI was obtained in order to confirm the diagnosis or determine tumor recurrence\/progression to help guide surgical and\/or radiation therapy management in cases in which MRI findings were indeterminate or equivocal.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Seventeen (85%) patients had undergone prior surgery and 11 (55%) underwent adjuvant radiation therapy. In 17 patients [68Ga]\u2010DOTATATE confirmed the presence of recurrent meningioma. A total of 49 meningiomas were identified (median: 2 meningiomas\/patient, range 0\u201014). There was excellent differentiation between meningioma and posttreatment change based on our approach of target lesion\/superior sagittal sinus maximum standardized uptake values ratio (16.6 vs. 1.6,\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .0001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>[68Ga]\u2010DOTATATE PET\/MRI is a promising tool in the assessment of both treatment na\u00efve and resected\/irradiated meningiomas, allowing improved diagnosis and extent of disease evaluation. Future prospective studies are needed to determine utility of [68Ga]\u2010DOTATATE PET\/MRI in treatment response assessment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jon.12632","type":"journal-article","created":{"date-parts":[[2019,5,20]],"date-time":"2019-05-20T08:47:19Z","timestamp":1558342039000},"page":"650-656","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":98,"title":["Gallium\u201068 DOTATATE PET in the Evaluation of Intracranial Meningiomas"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6470-5400","authenticated-orcid":false,"given":"Jana","family":"Ivanidze","sequence":"first","affiliation":[{"name":"Department of Diagnostic Radiology Weill Cornell Medicine  New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Roytman","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology Weill Cornell Medicine  New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eaton","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology Weill Cornell Medicine  New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajiv S.","family":"Magge","sequence":"additional","affiliation":[{"name":"Department of Neuro\u2010Oncology Weill Cornell Medicine  New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Pisapia","sequence":"additional","affiliation":[{"name":"Department of Pathology Weill Cornell Medicine  New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Liechty","sequence":"additional","affiliation":[{"name":"Department of Pathology Weill Cornell Medicine  New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Karakatsanis","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology Weill Cornell Medicine  New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohan","family":"Ramakrishna","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery Weill Cornell Medicine  New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Knisely","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Weill Cornell Medicine  New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodore H.","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery Weill Cornell Medicine  New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph R.","family":"Osborne","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology Weill Cornell Medicine  New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan C.","family":"Pannullo","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery Weill Cornell Medicine  New York NY"},{"name":"Department of Radiation Oncology Weill Cornell Medicine  New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,5,20]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/nox158"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-009-9934-0"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.3171\/2014.7.JNS131644"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.117.191932"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/nox112"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-009-1133-x"},{"key":"e_1_2_5_8_1","first-page":"13185","article-title":"Expression of somatostatin receptors (SSTR1\u2010SSTR5) in meningiomas 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