{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T23:12:04Z","timestamp":1777158724024,"version":"3.51.4"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,6,17]],"date-time":"2019-06-17T00:00:00Z","timestamp":1560729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1 TR001079"],"award-info":[{"award-number":["UL1 TR001079"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000098","name":"NIH Clinical Center","doi-asserted-by":"publisher","award":["R21AG061643\u201001"],"award-info":[{"award-number":["R21AG061643\u201001"]}],"id":[{"id":"10.13039\/100000098","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000098","name":"NIH Clinical Center","doi-asserted-by":"publisher","award":["RO1HD086058"],"award-info":[{"award-number":["RO1HD086058"]}],"id":[{"id":"10.13039\/100000098","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Hypoxic\u2010ischemic injury (HII) is a major cause of neonatal death and neurodevelopmental disability. Head ultrasounds (HUS) in neonates with HII often show enhanced gray\/white matter differentiation. We assessed the significance of this finding in predicting white matter structural integrity measured by diffusion tensor imaging (DTI) in neonates with HII.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>We performed a quantitative region of interest\u2010based analysis of white and gray matter echogenicity within the cingulate gyrus on pre\u2010 and posthypothermia HUS. We also completed a quantitative analysis of fractional anisotropy (FA) and mean (MD), axial (AD), and radial (RD) diffusivity within the bilateral anterior and posterior centrum semiovale (CSO) on posthypothermia brain magnetic resonance imaging. For HUS studies, we calculated a white\u2010to\u2010gray matter echogenicity ratio (WGR) and subsequently correlated it to DTI measurements.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Forty\u2010two term neonates with HII who underwent hypothermia therapy were included. Significant correlation was found between prehypothermia WGR and MD, AD, and RD values in the left anterior CSO (<jats:italic>r<\/jats:italic> = .38\u2010.40, <jats:italic>P<\/jats:italic> = .02). Prehypothermia WGR also correlated with the following: MD and RD in the right anterior CSO (<jats:italic>r<\/jats:italic> = .35\u2010.36, <jats:italic>P<\/jats:italic> = .04), MD and AD in the right posterior CSO (<jats:italic>r<\/jats:italic> = .32\u2010.45, <jats:italic>P<\/jats:italic> = .008\u2010.03), and AD in the left posterior CSO (<jats:italic>r<\/jats:italic> = .47, <jats:italic>P<\/jats:italic> = .005). No significant correlation was found either between prehypothermia WGR and FA values in the bilateral anterior and posterior CSO or between posthypothermia WGR and all DTI scalars in the bilateral anterior and posterior CSO.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Prehypothermia HUS WGR may predict posthypothermia white matter structural integrity and is potentially an early and easily obtainable biomarker of severity in neonatal HII.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jon.12644","type":"journal-article","created":{"date-parts":[[2019,6,17]],"date-time":"2019-06-17T18:31:39Z","timestamp":1560796299000},"page":"743-749","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Ultrasound Predicts White Matter Integrity after Hypothermia Therapy in Neonatal Hypoxic\u2010Ischemic Injury"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9277-8108","authenticated-orcid":false,"given":"Jacqueline","family":"Salas","sequence":"first","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics New\u2010York Presbyterian Brooklyn Methodist Hospital  Brooklyn NY"},{"name":"Neurosciences Intensive Care Nursery Group Johns Hopkins University School of Medicine  Baltimore MD"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nihaal","family":"Reddy","sequence":"additional","affiliation":[{"name":"Neurosciences Intensive Care Nursery Group Johns Hopkins University School of Medicine  Baltimore MD"},{"name":"Division of Pediatric Neuroradiology, Division of Pediatric Radiology, Russell H. Morgan Department of Radiology and Radiological Science Johns Hopkins University School of Medicine  Baltimore MD"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathryn A.","family":"Carson","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Johns Hopkins Bloomberg School of Public Health  Baltimore MD"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frances J.","family":"Northington","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics New\u2010York Presbyterian Brooklyn Methodist Hospital  Brooklyn NY"},{"name":"Division Neonatology, Department of Pediatrics Johns Hopkins University School of Medicine  Baltimore MD"},{"name":"Neurosciences Intensive Care Nursery Group Johns Hopkins University School of Medicine  Baltimore MD"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thierry A.G.M.","family":"Huisman","sequence":"additional","affiliation":[{"name":"Neurosciences Intensive Care Nursery Group Johns Hopkins University School of Medicine  Baltimore MD"},{"name":"Division of Pediatric Neuroradiology, Division of Pediatric Radiology, Russell H. 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