{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T06:12:28Z","timestamp":1790316748215,"version":"4.1.0"},"reference-count":53,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,8,13]],"date-time":"2019-08-13T00:00:00Z","timestamp":1565654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000261","name":"Multiple Sclerosis Society of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000261","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>BACKGROUND AND PURPOSE<\/jats:title><jats:p>Acquiring and interpreting quantitative myelin\u2010specific MRI data at an individual level is challenging because of technical difficulties and natural myelin variation in the population. To overcome these challenges, we used multiecho T<jats:sub>2<\/jats:sub>myelin water imaging (MWI) to create T<jats:sub>2<\/jats:sub>metric healthy population atlases that depict the mean and variation of myelin water fraction (MWF), and intra\u2010 and extracellular water mobility as described by geometric mean T<jats:sub>2<\/jats:sub>(IEGMT<jats:sub>2<\/jats:sub>).<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Cervical cord MWI was performed at 3T on 20 healthy individuals (10M\/10F, mean age: 36 years) and 3 relapsing remitting multiple sclerosis (RRMS) participants (1M\/2F, age: 39\/42\/37 years). Anatomical data were collected for the purpose of image segmentation and registration. Atlases were created by coregistering and averaging T<jats:sub>2<\/jats:sub>metrics from all controls. Voxel\u2010wise<jats:italic>z<\/jats:italic>\u2010score maps from 3 RRMS participants were produced to demonstrate the preliminary utility of the MWF and IEGMT<jats:sub>2<\/jats:sub>atlases.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The average MWF atlas provides a representation of myelin in the spinal cord consistent with well\u2010known spinal cord anatomical characteristics. The IEGMT<jats:sub>2<\/jats:sub>atlas also depicted structural variations in the spinal cord.<jats:italic>Z<\/jats:italic>\u2010score analysis illustrated distinct abnormalities in MWF and IEGMT<jats:sub>2<\/jats:sub>in the 3 RRMS cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Our findings highlight the potential for using a quantitative T<jats:sub>2<\/jats:sub>relaxation metric atlas to visualize and detect pathology in spinal cord. Our MWF and IEGMT<jats:sub>2<\/jats:sub>atlases (URL:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/sourceforge.net\/projects\/mwi-spinal-cord-atlases\/\">https:\/\/sourceforge.net\/projects\/mwi-spinal-cord-atlases\/<\/jats:ext-link>) can serve as normative references in the cervical spinal cord for other studies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jon.12659","type":"journal-article","created":{"date-parts":[[2019,8,13]],"date-time":"2019-08-13T07:44:19Z","timestamp":1565682259000},"page":"50-57","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Myelin Water Fraction and Intra\/Extracellular Water Geometric Mean T<sub>2<\/sub>Normative Atlases for the Cervical Spinal Cord from 3T MRI"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5052-1424","authenticated-orcid":false,"given":"Hanwen","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Physics &amp; Astronomy University of British Columbia Vancouver Canada"},{"name":"International Collaboration on Repair Discoveries University of British Columbia Vancouver Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1456-7967","authenticated-orcid":false,"given":"Emil","family":"Ljungberg","sequence":"additional","affiliation":[{"name":"Department of Neuroimaging Institute of Psychiatry Psychology and Neuroscience, King's College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6107-5610","authenticated-orcid":false,"given":"Adam V.","family":"Dvorak","sequence":"additional","affiliation":[{"name":"Department of Physics &amp; Astronomy University of British Columbia Vancouver Canada"},{"name":"International Collaboration on Repair Discoveries University of British Columbia Vancouver Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8334-3740","authenticated-orcid":false,"given":"Lisa Eunyoung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Medicine University of British Columbia Vancouver Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jackie T.","family":"Yik","sequence":"additional","affiliation":[{"name":"Department of Physics &amp; Astronomy University of British Columbia Vancouver Canada"},{"name":"International Collaboration on Repair Discoveries University of British Columbia Vancouver Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8515-5858","authenticated-orcid":false,"given":"Erin L.","family":"MacMillan","sequence":"additional","affiliation":[{"name":"Philips, Markham Canada"},{"name":"School of Mechatronic Systems Engineering Simon Fraser University Canada"},{"name":"Department of Radiology University of British Columbia Vancouver Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Barlow","sequence":"additional","affiliation":[{"name":"Philips, Markham Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1121-5571","authenticated-orcid":false,"given":"David K.B.","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Medicine University of British Columbia Vancouver Canada"},{"name":"Department of Radiology University of British Columbia Vancouver Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0351-9639","authenticated-orcid":false,"given":"Anthony","family":"Traboulsee","sequence":"additional","affiliation":[{"name":"Department of Medicine University of British Columbia 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