{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T12:52:26Z","timestamp":1777467146509,"version":"3.51.4"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T00:00:00Z","timestamp":1588896000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND AND PURPOSE<\/jats:title>\n                    <jats:p>This study's purpose is to correlate location and metabolic activity of developmental venous anomalies (DVAs) in epilepsy patients to the seizure focus as determined by ictal\/interictal encephaloelectrogram (EEG).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      A retrospective search was performed for epilepsy patients with DVAs who underwent brain\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010fluorodeoxyglucose positron emission tomography (\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010FDG\u2010PET) and magnetic resonance imaging (MRI). MRI exams were analyzed to characterize DVA location and associated structural findings. MRI and PET images were co\u2010registered and assessment of\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010FDG uptake in the DVA territory was performed. The electronic medical record was reviewed for each subject to determine seizure semiology and site of seizure focus by ictal\/interictal EEG.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Twenty\u2010eight DVAs in 25 patients were included. Twelve DVAs demonstrated regional metabolic abnormality on\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010FDG\u2010PET. There was no significant correlation between DVA site and seizure focus on EEG. DVA location was concordant with EEG seizure focus in three subjects, and all three demonstrated hypometabolism on\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010FDG\u2010PET. This significance remains indeterminate, as one of these DVAs was associated with cavernoma, which could serve as the true seizure focus, and one of the patients underwent resection of the DVA without decrease in seizure frequency. Furthermore, there was no statistically significant relationship between DVA metabolic activity and DVA\u2010EEG lobar or laterality concordance.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>\n                      In this sample, there is no significant correlation between location of DVA and seizure focus, and hypometabolism within the DVA territory is not predictive of EEG\/DVA co\u2010localization. As use of\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010FDG\u2010PET for evaluation of epilepsy increases, knowledge of this poor correlation is important to avoid diagnostic confusion and potentially unnecessary surgery in epilepsy patients.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jon.12722","type":"journal-article","created":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T14:30:31Z","timestamp":1588948231000},"page":"544-550","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Epilepsy Lesion Localization is not Predicted by Developmental Venous Anomaly Location or its FDG\u2010PET Metabolic Activity"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7966-9377","authenticated-orcid":false,"given":"Jillian W.","family":"Lazor","sequence":"first","affiliation":[{"name":"Department of Neuroradiology The Hospital of the University of Pennsylvania  Philadelphia PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joel M.","family":"Stein","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology The Hospital of the University of Pennsylvania  Philadelphia PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James Eric","family":"Schmitt","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology The Hospital of the University of Pennsylvania  Philadelphia PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathryn A.","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Neurology The Hospital of the University of Pennsylvania  Philadelphia PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seyed Ali","family":"Nabavizadeh","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology The Hospital of the University of Pennsylvania  Philadelphia PA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,5,8]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1978.00500290069012"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.116.016145"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.67.2.234"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01743138"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.139.1.7208947"},{"key":"e_1_2_5_7_1","first-page":"49","article-title":"Cryptic vascular malformations","volume":"38","author":"Wilson CB","year":"1992","journal-title":"Clin Neurosurg"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurad.2009.09.002"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-010-0739-9"},{"key":"e_1_2_5_10_1","first-page":"1549","article-title":"Atypical MR imaging perfusion in developmental venous anomalies","volume":"25","author":"Camacho DLA","year":"2004","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A3516"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A3900"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jon.12119"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A4172"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acra.2018.05.021"},{"key":"e_1_2_5_16_1","first-page":"1340","article-title":"Performance of a brain PET camera based on anger\u2010logic gadolinium oxyorthosilicate detectors","volume":"44","author":"Karp JS","year":"2003","journal-title":"J Nucl Med"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1109\/23.597009"},{"key":"e_1_2_5_18_1","unstructured":"R Core Team.R: a language and environment for statistical computing. 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