{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T21:26:14Z","timestamp":1790889974331,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,7,10]],"date-time":"2020-07-10T00:00:00Z","timestamp":1594339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>BACKGROUND AND PURPOSE<\/jats:title><jats:p>Although transcranial Doppler detects microembolic signals (MES) in numerous settings, the practical significance of such findings remains unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Clinical information from ischemic stroke or transient ischemic attack patients (<jats:italic>n<\/jats:italic> = 248) who underwent embolic monitoring from January 2015 to December 2018 was obtained.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>MES were found in 15% of studies and ischemic recurrence was seen in 11% of patients (over 7 \u00b1 6 days). Patients with MES had more lacunes than those without MES (1 \u00b1 3 vs. 1 \u00b1 2, <jats:italic>P<\/jats:italic> = .016), were more likely to have ischemic recurrence (37% vs. 6%, <jats:italic>P<\/jats:italic> &lt; .001), undergo a future revascularization procedure (26% vs. 10%, <jats:italic>P<\/jats:italic> = .005), have a longer length of stay (9 vs. 4 days, <jats:italic>P<\/jats:italic> = .043), and have worse functional disability at discharge (modified Rankin Scale 3\u20106, 66% vs. 34%, <jats:italic>P<\/jats:italic> &lt; .001). After controlling for several relevant cofactors, patients with MES were more likely to have ischemic recurrence (HR 4.90, 95% CI 2.16\u201011.09, <jats:italic>P<\/jats:italic> &lt; .001), worse functional disability (OR 3.31, 95% CI 1.22\u20108.99, <jats:italic>P<\/jats:italic> = .019), and longer length of stays (\u03b2 = .202, <jats:italic>P<\/jats:italic> &lt; .001).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>MES may help to risk stratify patients as their presence is associated with ischemic recurrence and worse outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jon.12749","type":"journal-article","created":{"date-parts":[[2020,7,10]],"date-time":"2020-07-10T12:09:35Z","timestamp":1594382975000},"page":"882-889","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Microembolic Signals Detected by Transcranial Doppler Predict Future Stroke and Poor Outcomes"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2313-977X","authenticated-orcid":false,"given":"Alvin S.","family":"Das","sequence":"first","affiliation":[{"name":"Department of Neurology Brigham and Women's Hospital, Harvard Medical School  Boston MA"},{"name":"Department of Neurology Massachusetts General Hospital, Harvard Medical School  Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2958-3484","authenticated-orcid":false,"given":"Robert W.","family":"Regenhardt","sequence":"additional","affiliation":[{"name":"Department of Neurology Massachusetts General Hospital, Harvard Medical School  Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"LaRose","sequence":"additional","affiliation":[{"name":"Department of Neurology Brigham and Women's Hospital, Harvard Medical School  Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew D.","family":"Monk","sequence":"additional","affiliation":[{"name":"Department of Neurology Brigham and Women's Hospital, Harvard Medical School  Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro M.","family":"Castro","sequence":"additional","affiliation":[{"name":"Department of Neurology, Centro Hospital Universit\u00e1rio S\u00e3o Jo\u00e3o Faculty of Medicine, University of Porto  Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faheem G.","family":"Sheriff","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery The University of Texas Health Science Center at Houston, McGovern Medical School  Houston TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farzaneh A.","family":"Sorond","sequence":"additional","affiliation":[{"name":"Department of Neurology Northwestern Memorial Hospital, Feinberg School of Medicine  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