{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T19:51:57Z","timestamp":1788983517489,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,11,6]],"date-time":"2020-11-06T00:00:00Z","timestamp":1604620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>BACKGROUND AND PURPOSE<\/jats:title><jats:p>Hashimoto's thyroiditis (HT) is a type of autoimmune thyroid disease. Diffusion tensor imaging (DTI) can evaluate microstructural brain involvement in various diseases. We aimed to investigate whether there were any DTI differences in patients with HT, and the relationship between DTI values and disease duration time and thyroid peroxidase antibodies (TPOAb) levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>We prospectively included 36 patients with HT (mean age 41.6 \u00b1 13.8 years, range 18\u201064 years) and 18 age and sex\u2010matched healthy control subjects (mean age 41.6 \u00b1 13.1 years, range 18\u201063 years). All patients were euthyroid at the time of imaging. Fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) values of 15 distinct neuroanatomical locations were measured and compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>FA values of the patients with HT were lower in cingulum, globus pallidus (GP), cerebellar white matter (CWM) than the control (<jats:italic>P<\/jats:italic> = .019, .002, and &lt;.001, respectively). MD values of the CWM in patients were higher than the control (<jats:italic>P<\/jats:italic> = .008). AD values of patients with HT were lower in the cingulum, posterior limbs of the internal capsule, GP, and putamen (<jats:italic>P<\/jats:italic> = .038, .038, .030, and .045, respectively). RD values of cingulum and CWM in HT were higher than controls (<jats:italic>P<\/jats:italic> &lt;.001 and <jats:italic>P<\/jats:italic> = .011, respectively). There was a negative relationship between the FA values of PLIC and a positive relationship between the MD values of the corona radiata and TPOAb levels were detected.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>The current DTI study presented microstructural changes in the neurocognitive\u2010related areas that may be related to accompanying neurological findings in HT.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jon.12804","type":"journal-article","created":{"date-parts":[[2020,11,6]],"date-time":"2020-11-06T15:19:30Z","timestamp":1604675970000},"page":"215-221","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Brain Diffusion Tensor Imaging Findings in Hashimoto's Thyroiditis"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7311-6969","authenticated-orcid":false,"given":"Mehmet Ali","family":"Gultekin","sequence":"first","affiliation":[{"name":"Department of Radiology, Faculty of Medicine Bezmialem Vakif University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3869-0524","authenticated-orcid":false,"given":"Dilek Hacer","family":"Cesme","sequence":"additional","affiliation":[{"name":"Department of Radiology, Faculty of Medicine Bezmialem Vakif University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1315-264X","authenticated-orcid":false,"given":"Ozcan","family":"Karaman","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Faculty of Medicine Bezmialem Vakif University  Istanbul 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