{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:48:43Z","timestamp":1790776123925,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,12,8]],"date-time":"2020-12-08T00:00:00Z","timestamp":1607385600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND AND PURPOSE<\/jats:title>\n                    <jats:p>Gait impairment is a hallmark of Parkinson's disease (PD). Natural walking involves more cognitive demand than treadmill walking or in\u2010laboratory walking tests because patients have to actively work on navigation and top\u2010down cognitive control which taxes cognitive reserve in the prefrontal cortex. To mimic the prefrontal engagement occurring with natural walking in a controlled and safe environment, dual\u2010task (DT) treadmill walking has been developed. In this study, we tested the feasibility of imaging DT walking\u2010related changes in brain glucose metabolism in patients with PD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Fifteen patients with PD were scanned with fluorodeoxyglucose (FDG) positron emission tomography. Five patients performed DT walking, and 10 patients were rested during the FDG uptake period. First, the images were contrasted between the groups. Second, the walking\u2010related brain glucose metabolism was inspected at the individual level.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Consistently increased glucose metabolism was identified in DT walking versus rest in the primary visual\/sensorimotor areas, thalamus, superior colliculus, and cerebellum. In individual level analysis, patients with less progressed disease (\n                      <jats:italic>n<\/jats:italic>\n                      = 3) showed prefrontal activity during DT walking while patients with more progressed disease (\n                      <jats:italic>n<\/jats:italic>\n                      = 2) did not.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>This study confirms the feasibility of imaging glucose metabolism during DT walking in patients with PD. We also report that during DT walking, there is a lesser degree of prefrontal engagement in the patients with more progressed disease compared to those with less progressed disease, implying increased degrees of frontal dysfunction with PD progression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jon.12812","type":"journal-article","created":{"date-parts":[[2020,12,8]],"date-time":"2020-12-08T19:15:43Z","timestamp":1607454943000},"page":"356-362","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Imaging Cerebral Glucose Metabolism during Dual\u2010Task Walking in Patients with Parkinson's disease"],"prefix":"10.1111","volume":"31","author":[{"given":"Tony","family":"Szturm","sequence":"first","affiliation":[{"name":"College of Rehabilitation Sciences University of Manitoba  Winnipeg Manitoba Canada"},{"name":"Graduate Program in Biomedical Engineering University of Manitoba  Winnipeg Manitoba Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iman","family":"Beheshti","sequence":"additional","affiliation":[{"name":"Department of Human Anatomy and Cell Science University of Manitoba  Winnipeg Manitoba Canada"},{"name":"Kleysen Institute for Advanced Medicine Health Science Centre  Winnipeg Manitoba Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhuvan","family":"Mahana","sequence":"additional","affiliation":[{"name":"College of Rehabilitation Sciences University of Manitoba  Winnipeg Manitoba Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas E","family":"Hobson","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Manitoba  Winnipeg Manitoba Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Goertzen","sequence":"additional","affiliation":[{"name":"Graduate Program in Biomedical Engineering University of Manitoba  Winnipeg Manitoba Canada"},{"name":"Department of Radiology University of Manitoba  Winnipeg Manitoba Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Hyun","family":"Ko","sequence":"additional","affiliation":[{"name":"Graduate Program in Biomedical Engineering University of Manitoba  Winnipeg Manitoba Canada"},{"name":"Department of Human Anatomy and Cell Science University of Manitoba  Winnipeg Manitoba Canada"},{"name":"Kleysen Institute for Advanced Medicine Health Science Centre  Winnipeg Manitoba Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,8]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2004.01.025"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-015-7865-6"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23868"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1037\/pne0000076"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnp.12028"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2007.126599"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20513"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/1545968316650426"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-161240"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31325-3"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2017.00105"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glu052"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-150536"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2019.116095"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/gly210"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gaitpost.2012.11.008"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.118.218248"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2019.01217"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.55.3.181"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-60327-426-5"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318219dc77"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.27014"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archger.2017.07.013"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gaitpost.2018.04.011"},{"key":"e_1_2_5_26_1","unstructured":"BhattM.Evaluation of a computer game based rehabilitation system for assessment of balance and gait impairments in individuals with Parkinson's disease. 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