{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:34:52Z","timestamp":1747186492996,"version":"3.40.5"},"reference-count":66,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,12,13]],"date-time":"2020-12-13T00:00:00Z","timestamp":1607817600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>BACKGROUND AND PURPOSE<\/jats:title><jats:p>The cognitive decline in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is assumed to be due to a cortical\u2010subcortical disconnection secondary to damage to the cerebral white matter (WM). Using resting state functional MRI (rsfMRI) and analysis of the regional homogeneity (ReHo), we examined a group of CADASIL patients and a group of healthy subjects in order to: (1) explore possible differences between the two groups; and (2) to assess, in CADASIL patients, whether any ReHo abnormalities correlate with individual burdens of WM T<jats:sub>2<\/jats:sub>\u2010weighted hyperintensity and diffusion tensor imaging (DTI)\u2010derived index of mean diffusivity (MD) of the cerebral WM, an index reflecting microstructural damage in CADASIL.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Twenty\u2010three paucisymptomatic CADASIL patients (13 females; age mean \u00b1 standard deviation = 43.6 \u00b1 11.1 years; three symptomatic and 20 with no or few symptoms) and 16 healthy controls (nine females; age 46.6 \u00b1 11.0 years) were examined with T<jats:sub>1<\/jats:sub>\u2010weighted, T<jats:sub>2<\/jats:sub>\u2010weighted fluid attenuated inversion recovery images, DTI, and rsfMRI.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>When compared to controls, CADASIL patients showed four clusters of significantly lower ReHo values in cortical areas belonging to networks involved in inhibition and attention, including the right insula, the left superior frontal gyrus, and the bilateral anterior cingulated cortex. ReHo changes did not correlate with an individual patient's lesion burden or MD.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>This study reveals decreased ReHo of rsfMRI signals in cortical areas involved in inhibition and attention processes, suggesting a potential role for these functional cortical changes in CADASIL.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jon.12821","type":"journal-article","created":{"date-parts":[[2020,12,13]],"date-time":"2020-12-13T22:49:58Z","timestamp":1607899798000},"page":"348-355","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Altered Regional Brain Homogeneity of BOLD Signal in CADASIL: A Resting State fMRI Study"],"prefix":"10.1111","volume":"31","author":[{"given":"Stefano","family":"Orsolini","sequence":"first","affiliation":[{"name":"Department of Electrical, Electronic, and Information Engineering \u201cGuglielmo Marconi\u201d University of Bologna  Cesena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Marzi","sequence":"additional","affiliation":[{"name":"Department of Electrical, Electronic, and Information Engineering \u201cGuglielmo Marconi\u201d University of Bologna  Cesena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gioele","family":"Gavazzi","sequence":"additional","affiliation":[{"name":"Department of Integrated Imaging IRCCS SDN  Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Bianchi","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Biomedical Sciences \u201cMario Serio\u201d University of Florence  Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilia","family":"Salvadori","sequence":"additional","affiliation":[{"name":"IRCSS Don Carlo Gnocchi  Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Giannelli","sequence":"additional","affiliation":[{"name":"Unit of Medical Physics Pisa University Hospital \u201cAzienda Ospedaliero\u2010Universitaria Pisana\u201d  Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ida","family":"Donnini","sequence":"additional","affiliation":[{"name":"IRCSS Don Carlo Gnocchi  Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Rinnoci","sequence":"additional","affiliation":[{"name":"IRCSS Don Carlo Gnocchi  Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Pescini","sequence":"additional","affiliation":[{"name":"Stroke Unit Careggi University Hospital  Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonardo","family":"Pantoni","sequence":"additional","affiliation":[{"name":"Stroke and Dementia Laboratory, Department of Biomedical and Clinical Sciences \u201cL. 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