{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T06:15:50Z","timestamp":1790662550693,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,1,21]],"date-time":"2021-01-21T00:00:00Z","timestamp":1611187200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>BACKGROUND AND PURPOSE<\/jats:title><jats:p>Vestibular symptoms after concussion are common and associated with protracted recovery. The purpose of this study is to define resting\u2010state functional MRI (rs\u2010fMRI) brain connectivity alterations in patients with postconcussion vestibular dysfunction (PCVD) and correlations between rs\u2010fMRI connectivity and symptoms provoked during Vestibular\/Ocular\u2010Motor Screening (VOMS) assessment.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Prospective IRB approved study. Study group: 12 subjects with subacute PCVD (2\u201010 weeks); control group: 10 age\u2010matched subjects without history of concussion or vestibular impairment. Both groups underwent clinical vestibular assessment. rs\u2010fMRI was acquired on 3.0T Siemens Trio with a 12\u2010channel head coil. rs\u2010fMRI data analysis included independent component analysis\u2010based functional connectivity group differences, graph theory analysis, and ROI\u2010to\u2010ROI connectivity correlation analysis with VOMS clinical derivatives. Group difference maps between resting\u2010state networks were calculated using dual regression method and corrected for multiple comparisons. Correlation analysis between ROI\u2010to\u2010ROI rs\u2010fMRI brain activation and VOMS assessment ratings was performed using Pearson correlation coefficient, with a significance threshold of<jats:italic>P<\/jats:italic>\u2264 .05.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Compared to controls, PCVD group demonstrated significantly increased rs\u2010fMRI connectivity between the default\u2010mode network and right middle frontal gyrus and right postcentral gyrus; and between a vestibular\u2010sensorimotor network and right prefrontal cortex. Significant positive correlations were found between clinical derivative VOMS scores and components of the vestibular, visual networks, and multisensory processing cortical representations.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Altered rs\u2010fMRI brain connectivity with increased connectivity of visual input, multisensory processing, and spatial memory in PCVD is correlative with clinical derivative VOMS scores, suggesting maladaptive brain plasticity underlying vestibular symptomatology.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jon.12834","type":"journal-article","created":{"date-parts":[[2021,1,21]],"date-time":"2021-01-21T20:22:33Z","timestamp":1611260553000},"page":"277-286","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Alterations in Resting\u2010State Functional Brain Connectivity and Correlations with Vestibular\/Ocular\u2010Motor Screening Measures in Postconcussion Vestibular Dysfunction"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3110-7914","authenticated-orcid":false,"given":"Anna","family":"Trofimova","sequence":"first","affiliation":[{"name":"Department of Radiology and Imaging Sciences Emory University Atlanta GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0841-5297","authenticated-orcid":false,"given":"Jeremy L.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Radiology and Imaging Sciences Emory University Atlanta GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3143-5835","authenticated-orcid":false,"given":"Vishwadeep","family":"Ahluwalia","sequence":"additional","affiliation":[{"name":"Georgia Statue University\/Georgia Tech Center for Advanced Brain Imaging Atlanta GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1565-5838","authenticated-orcid":false,"given":"Julia","family":"Hurtado","sequence":"additional","affiliation":[{"name":"Shepherd Center Atlanta GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8012-1579","authenticated-orcid":false,"given":"Russell K.","family":"Gore","sequence":"additional","affiliation":[{"name":"Shepherd Center Atlanta GA"},{"name":"Wallace H. 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