{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T02:34:31Z","timestamp":1793932471717,"version":"4.8.0"},"reference-count":50,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,2,8]],"date-time":"2021-02-08T00:00:00Z","timestamp":1612742400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1005492"],"award-info":[{"award-number":["1005492"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>BACKGROUND AND PURPOSE<\/jats:title><jats:p>Recently, there has been growing interest in the glymphatic system (the functional waste clearance pathway for the central nervous system and its role in flushing solutes (such as amyloid \u00df and tau), metabolic, and other cellular waste products in the brain. Herein, we investigate a recent potential biomarker for glymphatic activity (the diffusion tensor imaging along the perivascular space [DTI\u2010ALPS] parameter) using diffusion MRI imaging in an elderly cohort comprising 10 cognitively normal, 10 mild cognitive impairment (MCI), and 16 Alzheimer's disease (AD).<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>All 36 participants imaged on a Siemens 3.0T Tim Trio. Single\u2010SE diffusion weighted Echo\u2010planar imaging scans were acquired as well as T1 magnetization prepared rapid gradient echo, T2 axial, and susceptibility weighted imaging. Three millimeter regions of interest were drawn in the projection and association fibers adjacent to the medullary veins at the level of the lateral ventricle. The DTI\u2010ALPS parameter was calculated in these regions and correlated with cognitive status, Mini\u2010Mental State Examination (MMSE), and ADASCog11 measures.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Significant correlations were found between DTI\u2010ALPS and MMSE and ADASCog11 in the right hemisphere adjusting for age, sex, and APoE \u03b54 status. Significant differences were also found in the right DTI\u2010ALPS indices between cognitively normal and AD groups (<jats:italic>P<\/jats:italic> &lt; .026) and MCI groups (<jats:italic>P<\/jats:italic> &lt; .025) in a univariate general linear model corrected for age, sex, and APoE \u03b54. Significant differences in apparent diffusion coefficient between cognitively normal and AD groups were found in the right projection fibers (<jats:italic>P<\/jats:italic> = .028).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Further work is needed to determine the utility of DTI\u2010ALPS index in larger elderly cohorts and whether it measures glymphatic activity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jon.12837","type":"journal-article","created":{"date-parts":[[2021,2,10]],"date-time":"2021-02-10T05:29:55Z","timestamp":1612934995000},"page":"569-578","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":185,"title":["Assessment of the DTI\u2010ALPS Parameter Along the Perivascular Space in Older Adults at Risk of Dementia"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8949-4139","authenticated-orcid":false,"given":"Christopher E.","family":"Steward","sequence":"first","affiliation":[{"name":"Department of Medicine and Radiology University of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijay K.","family":"Venkatraman","sequence":"additional","affiliation":[{"name":"Department of Medicine and Radiology University of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine","family":"Lui","sequence":"additional","affiliation":[{"name":"Department of Medicine and Radiology University of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles B.","family":"Malpas","sequence":"additional","affiliation":[{"name":"Department of Medicine and Radiology University of Melbourne  Melbourne Victoria Australia"},{"name":"Department of Neurology Royal Melbourne Hospital  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn A.","family":"Ellis","sequence":"additional","affiliation":[{"name":"Academic Unit for Psychiatry of Old Age, Department of Psychiatry University of Melbourne  Melbourne Victoria Australia"},{"name":"Melbourne School of Psychological Sciences University of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth V.","family":"Cyarto","sequence":"additional","affiliation":[{"name":"Bolton Clarke Research Institute  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucy","family":"Vivash","sequence":"additional","affiliation":[{"name":"Department of Medicine and Radiology University of Melbourne  Melbourne Victoria Australia"},{"name":"Department of Neurology Royal Melbourne Hospital  Melbourne Victoria Australia"},{"name":"Department of Neurosciences, Central Clinical School Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terence J.","family":"O'Brien","sequence":"additional","affiliation":[{"name":"Department of Medicine and Radiology University of Melbourne  Melbourne Victoria Australia"},{"name":"Department of Neurosciences, Central Clinical School Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis","family":"Velakoulis","sequence":"additional","affiliation":[{"name":"Neuropsychiatry Unit, Royal Melbourne Hospital &amp; 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