{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T19:32:09Z","timestamp":1780860729645,"version":"3.54.1"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,2,10]],"date-time":"2021-02-10T00:00:00Z","timestamp":1612915200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>BACKGROUND AND PURPOSE<\/jats:title><jats:p>Perfusion imaging can risk stratify patients with symptomatic intracranial stenosis. We aim to determine the association between perfusion delay and length of hospital stay (LOS) in symptomatic middle cerebral artery (MCA) stenosis patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>This is a retrospective study of consecutive patients admitted to a comprehensive stroke center over 5 years with ischemic stroke or transient ischemic attack (TIA) within 7 days of symptom onset due to MCA stenosis (50\u201099%) and underwent perfusion imaging. Patients were divided into three groups: mismatch volume \u2265 15 cc based on T max &gt; 6 second delay, T max 4\u20106 second delay, and &lt;4\u00a0second delay. The outcome was LOS, both as a continuous variable and categorical (\u22657 days [prolonged LOS] vs. &lt;7\u00a0days). We used adjusted regression analyses to determine the association between perfusion categories and LOS.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>One hundred and seventy eight of 194 patients met the inclusion criteria. After adjusting for age and NIHSS, T max &gt;6 second mismatch was associated with prolonged LOS (OR 2.94 95% CI 1.06\u20108.18; <jats:italic>P<\/jats:italic> = .039), but T max 4\u20106 second was not (OR 1.45 95% CI .46\u20104.58, <jats:italic>P<\/jats:italic> = .528). We found similar associations when LOS was a continuous variable for T max &gt; 6 second (\u03b2 coefficient = 2.01, 95% CI .05\u20103.97, <jats:italic>P<\/jats:italic> = .044) and T max 4\u20106 second (\u03b2 coefficient = 1.24, 95% CI \u2013.85 to 3.34, <jats:italic>P<\/jats:italic> = .244).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>In patients with symptomatic MCA stenosis, T max &gt; 6 second perfusion delay is associated with prolonged LOS. Prospective studies are needed to validate our findings.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jon.12839","type":"journal-article","created":{"date-parts":[[2021,2,11]],"date-time":"2021-02-11T03:13:32Z","timestamp":1613013212000},"page":"475-479","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Impaired Distal Perfusion Predicts Length of Hospital Stay in Patients with Symptomatic Middle Cerebral Artery Stenosis"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0031-1004","authenticated-orcid":false,"given":"Shadi","family":"Yaghi","sequence":"first","affiliation":[{"name":"Department of Neurology NYU Langone Health  New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8178-8597","authenticated-orcid":false,"given":"Adam de","family":"Havenon","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Utah  Salt Lake City UT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tristan","family":"Honda","sequence":"additional","affiliation":[{"name":"Department of Neurology University of California at Los Angeles  Los Angeles CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason D.","family":"Hinman","sequence":"additional","affiliation":[{"name":"Department of Neurology University of California at Los Angeles  Los Angeles CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radoslav","family":"Raychev","sequence":"additional","affiliation":[{"name":"Department of Neurology University of California at Los Angeles  Los Angeles CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Latisha K.","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Neurology University of California at Los Angeles  Los Angeles 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