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However, conventional neuroimaging often fails to provide enough diagnostic findings in patients with neurodegenerative disorders. In this context, different MRI sequences are currently under investigation to facilitate the accurate diagnosis of such disorders. Susceptibility\u2010weighted imaging (SWI) is an innovative MRI technique that utilizes \u201cmagnitude\u201d and \u201cphase\u201d images to produce an image contrast that is sensitive for the detection of susceptibility differences of the tissues. As many neurodegenerative disorders are associated with accelerated iron deposition and\/or microhemorrhages in different parts of the brain, SWI can be applied to detect these diagnostic clues. For instance, in cerebral amyloid angiopathy, SWI can demonstrate cortical microhemorrhages, which are predominantly in the frontal and parietal regions. Or in Parkinson disease, abnormal swallow\u2010tail sign on high\u2010resolution SWI is highly diagnostic. Also, SWI is a useful sequence to detect the low signal intensity of precentral cortices in patients with amyotrophic lateral sclerosis. Being familiar with SWI findings in neurodegenerative disorders is critical for an accurate diagnosis. In this paper, the authors review the technical parameters of SWI, physiologic, and pathologic iron deposition in the brain, and the role of SWI in the evaluation of neurodegenerative disorders in daily practice.<\/jats:p>","DOI":"10.1111\/jon.12841","type":"journal-article","created":{"date-parts":[[2021,2,24]],"date-time":"2021-02-24T06:29:05Z","timestamp":1614148145000},"page":"459-470","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Susceptibility\u2010Weighted Imaging in Neurodegenerative Disorders: A Review"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5510-7062","authenticated-orcid":false,"given":"Houman","family":"Sotoudeh","sequence":"first","affiliation":[{"name":"Department of Radiology and Neurology University of Alabama at Birmingham (UAB)  Birmingham AL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir Hossein","family":"Sarrami","sequence":"additional","affiliation":[{"name":"University of Semnan  Semnan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian\u2010xiong","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Physics and Engineering University of Alabama at Birmingham (UAB)  Birmingham AL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Saadatpour","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Alabama at Birmingham (UAB)  Birmingham AL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Razaei","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Alabama at Birmingham (UAB)  Birmingham AL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siddhartha","family":"Gaddamanugu","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Alabama at Birmingham (UAB) and VA Hospital  Birmingham AL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gagandeep","family":"Choudhary","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Alabama at Birmingham (UAB)  Birmingham AL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omid","family":"Shafaat","sequence":"additional","affiliation":[{"name":"The Russell H. 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