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We assess the variability of manual segmentations of MRI\u2010DWI infarct volume.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Consecutive patients (May 2018 to May 2019) with the anterior circulation stroke and endovascularly treated were enrolled. All patients underwent 24\u2010 to 32\u2010hour follow\u2010up MRI. Three users manually segmented DWI infarct volumes slice by slice twice. The reference standard of DWI infarct volume was generated by the STAPLE algorithm. Intra\u2010 and interrater reliability was evaluated using the intraclass correlation coefficient (ICC) by comparing manual segmentations with the reference standard. Spatial measurements were evaluated using metrics of the Dice similarity coefficient (DSC). Volumetric measurements were compared using the lesion volume.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>The dataset consisted of 44 patients, mean (SD) age was 70.1 years (\u00b110.3), 43% were women, and median baseline NIHSS score was 16. Among three users, the mean DSC for MRI\u2010DWI infarct volume segmentations ranged from 80.6%\u00a0\u00b1\u00a011.7% to 88.6%\u00a0\u00b1\u00a07.5%, and the mean absolute volume difference was 2.8\u00a0\u00b1\u00a06.8 to 13.0\u00a0\u00b1\u00a014.0 ml. Interrater ICC among the users for DSC and infarct volume was .86 (95% confidence interval [95% CI]: .78\u2010.91) and .997 (95% CI: .995\u2010.998). Intrarater ICC for the three users was .83 (95% CI: .69\u2010.93), .84 (95% CI: .72\u2010.91), and .80 (95% CI: .64\u2010.89) for DSC, and .99 (95% CI: .987\u2010.996), .991 (95% CI: .983\u2010.995), and .996 (95% CI: .993\u2010.998) for infarct volume.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>Manual segmentation of infarct volume on follow\u2010up MRI\u2010DWI shows excellent agreement and good spatial overlap with the reference standard, suggesting its usefulness for measuring infarct volume on 24\u2010 to 32\u2010hour MRI\u2010DWI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jon.12850","type":"journal-article","created":{"date-parts":[[2021,3,30]],"date-time":"2021-03-30T05:07:07Z","timestamp":1617080827000},"page":"541-550","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["MRI 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