{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T19:32:42Z","timestamp":1769196762701,"version":"3.49.0"},"reference-count":58,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T00:00:00Z","timestamp":1620777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Purpose<\/jats:title><jats:p>Evaluation and treatment of acute ischemic syndromes, in the heart and brain, require vessel visualization by iodinated X\u2010ray contrast agents. However, these contrast agents can induce injury, in both the kidneys and target organs themselves. Sulfobutylether beta cyclodextrin (SBECD) added to iohexol (SBECD\u2010iohexol) (Captisol Enabled\u2010iohexol, Ligand Pharmaceuticals, Inc, San Diego, CA) is currently in clinical trials in cardiovascular procedures, to determine its relative renal safety in high\u2010risk patients. Preclinical studies showed that SBECD\u2010iohexol reduced contrast\u2010induced acute kidney injury in rodent models by blocking apoptosis. The current study was undertaken to determine whether SBECD\u2010iohexol is also cardioprotective, in the male rat ischemia\u2010reperfusion model, compared to iohexol alone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>After anesthesia, the left coronary artery was ligated for 30 min and the ligation released and reperfusion followed for 2 h prior to sacrifice. Groups 1\u20134 were injected in the tail vein 10 min prior to ischemia with: (1) vehicle; (2) iohexol; (3) SBECD; and (4) SBECD\u2010iohexol. Infarct size, hemodynamics, and serum markers were measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>An eight\u2010fold increase in serum creatine kinase in the iohexol\u2010alone group was observed, compared with no increase in the SBECD\u2010iohexol group. The mean arterial pressure and rate pressure product were depressed in the iohexol\u2010alone group, but not in the SBECD\u2010iohexol group, or controls. No difference in infarct size or serum creatinine among the groups was observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results of this study suggest that SBECD\u2010iohexol is superior to iohexol alone, for both the preservation of cardiomyocyte integrity and preservation of myocardial function in myocardial ischemia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jon.12873","type":"journal-article","created":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T13:16:55Z","timestamp":1620825415000},"page":"706-713","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A nephroprotective iodinated contrast agent with cardioprotective properties: A pilot study"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9319-4048","authenticated-orcid":false,"given":"Elizabeth S.","family":"Rowe","sequence":"first","affiliation":[{"name":"Neurrow Pharmaceuticals, Inc 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