{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T05:49:24Z","timestamp":1780379364178,"version":"3.54.1"},"reference-count":54,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,6,29]],"date-time":"2021-06-29T00:00:00Z","timestamp":1624924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Purpose<\/jats:title><jats:p>Early hearing loss causes several changes in the brain structure and function at multiple levels; these changes can be observed through neuroimaging. These changes are directly associated with sensory loss (hearing) and the acquisition of alternative communication strategies. Such plasticity changes in the brain might establish a different connectivity pattern with resting\u2010state networks (RSNs) and other brain regions. We performed resting\u2010state functional magnetic resonance imaging (rsfMRI) to evaluate these intrinsic modifications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used two methods to characterize the functional connectivity (FC) of RSN components in 20 prelingual deaf adults and 20 demographic\u2010matched hearing adults. rsfMRI data were analyzed using independent component analysis (ICA) and region\u2010of\u2010interest seed\u2010to\u2010voxel correlation analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In ICA, we identified altered FC of RSNs in the deaf group. RSNs with altered FC were observed in higher visual, auditory, default mode, salience, and sensorimotor networks. The findings of seed\u2010to\u2010voxel correlation analysis suggested increased temporal coherence with other neural networks in the deaf group compared with the hearing control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These findings suggest a highly diverse resting\u2010state connectivity pattern in prelingual deaf adults resulting from compensatory cross\u2010modal plasticity that includes both auditory and nonauditory regions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jon.12904","type":"journal-article","created":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T03:06:34Z","timestamp":1625108794000},"page":"1135-1145","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Alteration of brain resting\u2010state networks and functional connectivity in prelingual 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