{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:53:56Z","timestamp":1787165636137,"version":"build-2736575974"},"reference-count":71,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T00:00:00Z","timestamp":1628812800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Purpose<\/jats:title>\n                    <jats:p>We report the results of intra\u2010arterial injection of lidocaine in the middle meningeal artery in patients with intractable headache or status migrainosus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We treated\n                      <jats:italic>four patients<\/jats:italic>\n                      with intra\u2010arterial lidocaine (2 mg\/ml) in doses up to 50 mg in each middle meningeal artery via a microcatheter bilaterally (except in one patient). In two patients with intractable headache, the daily maximum intensity of headache (graded by 11\u2010point numeric rating scale) was recorded for 7 days postprocedure. In two patients\u00a0with status migrainosus,\u00a0migraine\u2010related disability 3 months prior and after treatment using\u00a0MIDAS (Migraine Disability Assessment) questionnaire was recorded.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Intra\u2010arterial lidocaine reduced the headache intensity from 8\/10 and 10\/10 to 0\/10 in the two patients with intractable headaches for 2 days (day 0 and day 1) postprocedure. Despite recurrence of headache on day 2, the intensity was less than preprocedure intensity up to the last day recorded (by 3 and 2 points on day 7). In\u00a0the two patients with\u00a0status migrainosus,\u00a0there was immediate reduction in headache intensity following intra\u2010arterial lidocaine. The\u00a0post treatment 3\u2010month MIDAS score was lower in both patients compared with pretreatment 3\u2010month score; 3 versus 30 and 55 versus 90. Severe disability preprocedure by MIDAS was reduced to little or no disability postprocedure in one patient.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Intra\u2010arterial lidocaine resulted in amelioration of headache in\u00a0patients with intractable headache and those with status migrainosus with improvement lasting longer than the short half\u2010life of lidocaine possibly related to central desensitization.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jon.12918","type":"journal-article","created":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T14:00:46Z","timestamp":1628863246000},"page":"1126-1134","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Intra\u2010arterial injection of lidocaine into middle meningeal artery to treat intractable headaches and severe 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