{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T11:19:25Z","timestamp":1778671165024,"version":"3.51.4"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,10,14]],"date-time":"2021-10-14T00:00:00Z","timestamp":1634169600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Purpose<\/jats:title><jats:p>To explore the application value and clinical significance of transcranial Doppler(TCD)in assessing leptomeningeal collateral flow (LMF) status in patients with unilateral middle cerebral artery (MCA) occlusion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Medical records of patients with unilateral MCA occlusion confirmed by digital subtraction angiography (DSA) were analyzed retrospectively. The patients were divided into three groups according to LMF status, and the laboratory and imaging results were collected. Cerebral blood flow velocity (CBFV) of MCA, anterior cerebral artery (ACA), and posterior cerebral artery (PCA) on the affected side (ipsilateral, i) and the healthy side (contralateral, c) were measured and recorded by TCD. The results of CBFV changes detected by TCD were compared with those of DSA, and the correlation between CBFV changes and LMF status was analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighty\u2010four patients with unilateral MCA occlusion were included. CBFViACA and CBFViPCA were significantly faster than CBFVcACA and CBFVcPCA in patients with good LMF status (<jats:italic>p<\/jats:italic>&lt;.05). There was a significant positive correlation between CBFViACA and LMF status (<jats:italic>r<\/jats:italic> = 0.697, <jats:italic>p<\/jats:italic>&lt;.001). There was statistical significance in receiver operating characteristic curve analysis of CBFViACA and CBFViPCA (<jats:italic>p<\/jats:italic>&lt;.05). The area under the curve of CBFViACA and CBFViPCA, respectively, was 0.879 and 0.678, and the best cutoff value was 82 and 60.5 cm\/s.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>TCD can assess LMF status by detecting the changes of flow velocity of intracranial vessels. CBFV of ACA and PCA in patients with MCA occlusion is significantly correlated with LMF status by DSA. Assessing LMF status, CBFViACA, CBFViACA\/CBFVcACA, and CBFViACA\/CBFViMCA has the great diagnostic value, which is of great significance in guiding MCA occlusion patients to choose individualized treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jon.12937","type":"journal-article","created":{"date-parts":[[2021,10,19]],"date-time":"2021-10-19T15:02:29Z","timestamp":1634655749000},"page":"179-186","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Leptomeningeal collateral flow in patients with middle cerebral artery occlusion assessed by transcranial Doppler"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2351-4736","authenticated-orcid":false,"given":"Na","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Neurology Second Affiliated Hospital of Harbin Medical University  Harbin P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhimin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology Harbin City Second Hospital  Harbin P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuai","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology Second Affiliated Hospital of Harbin Medical University  Harbin P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongshuang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Stomatology Shenzhen University General Hospital  Shenzhen P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Second Affiliated Hospital of Harbin Medical University  Harbin P. R. 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