{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T17:55:18Z","timestamp":1787680518156,"version":"build-2784847793"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,10,11]],"date-time":"2021-10-11T00:00:00Z","timestamp":1633910400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Purpose<\/jats:title><jats:p>Diffuse hemispheric gliomas, H3 G34\u2010mutant (DHGs\u2010G34m), are newly recognized malignant brain tumors characterized by histone gene mutations. However, the neuroradiologic characteristics of these tumors require elucidation. We reviewed the demographic, clinical, and neuroradiological features of DHGs\u2010G34m.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data were extracted using a database search in MEDLINE, SCOPUS, and Google Scholar in June 2021. Studies assessing pathologically proven DHGs\u2010G34m with each patient's information and neuroradiological findings were included. After screening and reviewing 332 abstracts, 12 articles including 56 cases met the criteria. We also added the findings for three patients evaluated in our hospital. Two board\u2010certified radiologists reviewed all demographic, clinical, and neuroradiological findings of each study. One board\u2010certified pathologist reviewed all pathological data of each study. Kaplan\u2013Meier analyses with log\u2010rank tests were performed to compare the survival between patients with different tumor margin characteristics (well\u2010delineated and ill\u2010defined).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median patient age at diagnosis was 19 years (range, 6\u201366 years), and 31\/59 patients (52.5%) were men. Supratentorial tumors were observed in all patients (59\/59, 100%). Frequent contact with leptomeninges (92.3%) and ependymal regions (87.5%) was observed. The 1\u2010 and 2\u2010year survival rates after initial surgery were 66.7% and 40.0%, respectively. DHGs\u2010G34m with ill\u2010defined and well\u2010delineated margins showed significant differences in survival (<jats:italic>p<\/jats:italic> = .04).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>DHGs\u2010G34m occur most often in the supratentorial regions of adolescents. Prognosis varies among patients. Evaluation of tumor margins may provide prognostic value.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jon.12939","type":"journal-article","created":{"date-parts":[[2021,10,14]],"date-time":"2021-10-14T02:38:37Z","timestamp":1634179117000},"page":"17-27","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Neuroimaging features of diffuse hemispheric glioma, H3 G34\u2010mutant: A case series and systematic review"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1186-8900","authenticated-orcid":false,"given":"Ryo","family":"Kurokawa","sequence":"first","affiliation":[{"name":"Division of Neuroradiology, Department of Radiology University of Michigan  Ann Arbor Michigan 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