{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T15:11:35Z","timestamp":1771254695497,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,12,27]],"date-time":"2021-12-27T00:00:00Z","timestamp":1640563200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2021,12,27]],"date-time":"2021-12-27T00:00:00Z","timestamp":1640563200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Purpose<\/jats:title>\n                    <jats:p>Stent retriever (SR) thrombectomy is commonly used for the treatment of emergent large vessel occlusion (ELVO) in acute ischemic stroke. Clot imaging parameters such as clot length, diameter, distance to the internal carotid artery terminus, and vessel angle where the SR is deployed may predict the likelihood of achieving first pass effect (FPE). Most of the proposed factors that seem to affect recanalization success have been studied individually, and conflicting data derived from clinical versus in vitro studies using 3\u2010dimensional printed models of intracranial circulation currently exist.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Using patient\u2010specific 3\u2010dimensional phantoms of the cervical and intracranial circulation, we simulated middle cerebral arteries (MCA) M1 and M2 occlusions treated with SR thrombectomy using Solitaire (Medtronic) or Trevo (Styker). Our primary outcome was FPE, defined as Thrombolysis in Cerebral Infarction score of 2c\n                      <jats:bold>\u2013<\/jats:bold>\n                      3 achieved after a single thrombectomy attempt. We also performed retrospective analysis of same clot imaging characteristics of consecutive cases of MCA occlusion and its association with FPE matching the 3\u2010dimensional in vitro experiments. Analysis was conducted using IBM SPSS Statistics Version 25 (IBM Corp., Armonk, NY). Chi\u2010square tests and bivariate logistic regressions were the main statistical tests used in analysis. A\n                      <jats:italic>p<\/jats:italic>\n                      \u2010value of less than .05 was considered to indicate statistical significance. Ninety\u2010five confidence intervals (95% CI) were generated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We compared 41 thrombectomy experiments performed using patient\u2010specific 3\u2010dimensional in vitro models with a retrospective cohort of 41 patients treated with SR thrombectomy. We found that in the in vitro cohort, higher MCA angulation was associated with a lower likelihood of FPE (odds ratio [OR]\u00a0=\u00a00.967, 95% CI\u00a0=\u00a00.944\u20100.991,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.008). Meanwhile in the in vivo cohort, higher MCA angulation was associated with a higher likelihood of FPE (OR\u00a0=\u00a01.039, 95% CI\u00a0=\u00a01.003\u20101.077,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.033). Neither clot length nor location of clot (M1 vs. M2) was associated with a difference in FPE rates in either cohort.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Comparison of SR thrombectomy performed during actual MCA occlusion cases versus patient\u2010specific 3\u2010dimensional replicas revealed MCA angulation as an independent predictor of procedure success or failure. However, the opposite direction of effect was observed between the two studied environments, indicating potential limitations of studying SR thrombectomy using 3\u2010dimensional models of LVO.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jon.12961","type":"journal-article","created":{"date-parts":[[2021,12,27]],"date-time":"2021-12-27T14:02:13Z","timestamp":1640613733000},"page":"436-441","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of stent retriever thrombectomy using 3\u2010dimensional patient\u2010specific models of intracranial circulation with actual middle cerebral artery occlusion thrombectomy cases"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5160-802X","authenticated-orcid":false,"given":"Elliot","family":"Pressman","sequence":"first","affiliation":[{"name":"Department of Neurosurgery and Brain Repair University of South Florida  Tampa Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelsey N.","family":"Sommer","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering University at Buffalo  Buffalo New York USA"},{"name":"Canon Stroke and Vascular Research Center University at Buffalo  Buffalo New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Waqas","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery University at Buffalo  Buffalo New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adnan H.","family":"Siddiqui","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering University at Buffalo  Buffalo New York USA"},{"name":"Canon Stroke and Vascular Research Center University at Buffalo  Buffalo New York USA"},{"name":"Department of Neurosurgery University at Buffalo  Buffalo New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ciprian N.","family":"Ionita","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering University at Buffalo  Buffalo New York USA"},{"name":"Canon Stroke and Vascular Research Center University at Buffalo  Buffalo New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maxim","family":"Mokin","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Brain Repair University of South Florida  Tampa Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,12,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2018.4510"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30242-4"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000430474"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.001972"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.00083"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.120.019988"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.120.030010"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.118.022987"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A5232"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.115.010044"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000442578"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.642877"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.120.032810"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A6865"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2014-011148"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2018-014468"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A4149"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-020-02525-6"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2017-013507"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.117.020125"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2019-015113"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-23998-w"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.558125"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-0998-4246"}],"container-title":["Journal 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