{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:54:12Z","timestamp":1773708852601,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,1,17]],"date-time":"2022-01-17T00:00:00Z","timestamp":1642377600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,1,17]],"date-time":"2022-01-17T00:00:00Z","timestamp":1642377600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Purpose<\/jats:title>\n                    <jats:p>The goal of this study was to assess the utility of diffusion\u2010weighted imaging (DWI) and dynamic contrast\u2010enhanced magnetic resonance imaging (DCE\u2010MRI) to distinguish sporadic vestibular schwannomas (VSs) from those related to neurofibromatosis type 2 (NF2).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively reviewed 265 patients pathologically diagnosed with VSs between January 2015 and October 2020 in a single institution. There were 28 patients (male: 19, female: 9; age 11\u201067 years) including 23 sporadic and five NF2\u2010related VSs, who had pretreatment DWI and DCE\u2010MRI. Normalized mean apparent diffusion coefficient (nADCmean) and DCE\u2010MRI parameters along with tumor characteristics were compared between sporadic and NF2\u2010related VSs as appropriate. The diagnostic performances were calculated based on the receiver operating characteristic curve analysis for the values that showed significant differences. To identify significant modalities, multivariate logistic regression analysis was performed using nADCmean and the combination of statistically significant DCE\u2010MRI parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      NADCmean, fractional volume of extracellular space (Ve), and forward volume transfer constant (Ktrans) were significantly different between sporadic and NF2\u2010related VSs (nADCmean: median 1.62 vs. 1.16,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.002; Ve: median 0.40 vs. 0.66,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.007; Ktrans: median 0.17 vs. 0.33,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.007), whereas fractional plasma volume (Vp), reverse\u00a0reflux rate\u00a0constant (Kep), and tumor characteristics were not. The diagnostic performances of nADCmean, Ve, and Ktrans were 0.93, 0.90, and 0.90 area under the curves with cutoffs of 1.46, 0.51, and 0.29, respectively. nADCmean and the combination of Ve and Ktrans were both chosen as significant differentiators by multivariate logistic regression analysis (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.027).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>DWI and DCE\u2010MRI are both promising modalities to distinguish sporadic and NF2\u2010related VSs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jon.12966","type":"journal-article","created":{"date-parts":[[2022,1,17]],"date-time":"2022-01-17T03:56:09Z","timestamp":1642391769000},"page":"554-560","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["RETRACTED: Neurofibromatosis type 2 versus sporadic vestibular schwannoma: The utility of MR diffusion and dynamic contrast\u2010enhanced imaging"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8992-2156","authenticated-orcid":false,"given":"Yoshiaki","family":"Ota","sequence":"first","affiliation":[{"name":"Division of Neuroradiology, Department of Radiology University of Michigan  Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Liao","sequence":"additional","affiliation":[{"name":"Division of Neuroradiology, Department of Radiology University of Michigan  Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aristides A.","family":"Capizzano","sequence":"additional","affiliation":[{"name":"Division of Neuroradiology, Department of Radiology University of Michigan  Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6913-5307","authenticated-orcid":false,"given":"Akira","family":"Baba","sequence":"additional","affiliation":[{"name":"Division of Neuroradiology, Department of Radiology University of Michigan  Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1186-8900","authenticated-orcid":false,"given":"Ryo","family":"Kurokawa","sequence":"additional","affiliation":[{"name":"Division of Neuroradiology, Department of Radiology University of Michigan  Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3907-9188","authenticated-orcid":false,"given":"Mariko","family":"Kurokawa","sequence":"additional","affiliation":[{"name":"Division of Neuroradiology, Department of Radiology University of Michigan  Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashok","family":"Srinivasan","sequence":"additional","affiliation":[{"name":"Division of Neuroradiology, Department of Radiology University of Michigan  Ann Arbor Michigan 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