{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T15:29:03Z","timestamp":1776785343303,"version":"3.51.2"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,1,31]],"date-time":"2022-01-31T00:00:00Z","timestamp":1643587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Purpose<\/jats:title><jats:p>Patients with a corticobasal syndrome (CBS) present a rare form of atypical parkinsonism characterized by asymmetric clinical symptoms and progressive motor and nonmotor impairment, such as apraxia, alien limb phenomenon, aphasia, myoclonus, dystonia, and cognitive impairment. At early stages, clinical differentiation between CBS and idiopathic Parkinson's disease (IPD) can be challenging.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using high\u2010resolution T1\u2010weighted images and voxel\u2010based morphometry (VBM), we sought to identify disease\u2010specific patterns of brain atrophy in a small sample of CBS and IPD patients at early stages of disease. We acquired MR images of 17 patients diagnosed with CBS and compared them with MR images of 17 subjects affected by IPD. Images were preprocessed and analyzed using VBM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>When compared to each other, the CBS and IPD patients of our cohort showed differences in regional gray and white matter volume depending on the diagnosis, specifically in the superior longitudinal fascicle.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In our small patients\u2019 group, VBM was able to detect changes in regional gray and white matter volume between patients affected by CBS and patients with IPD as early as 1.5\u20102 years after the onset of the first motor symptoms.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jon.12971","type":"journal-article","created":{"date-parts":[[2022,1,31]],"date-time":"2022-01-31T10:09:14Z","timestamp":1643623754000},"page":"720-727","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Brain volume patterns in corticobasal syndrome versus idiopathic Parkinson's disease"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9077-8793","authenticated-orcid":false,"given":"Stefano","family":"Ferrea","sequence":"first","affiliation":[{"name":"Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty Heinrich\u2010Heine\u2010University D\u00fcsseldorf  D\u00fcsseldorf Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederick Benjamin","family":"Junker","sequence":"additional","affiliation":[{"name":"Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty Heinrich\u2010Heine\u2010University D\u00fcsseldorf  D\u00fcsseldorf Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian Johannes","family":"Hartmann","sequence":"additional","affiliation":[{"name":"Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty Heinrich\u2010Heine\u2010University D\u00fcsseldorf  D\u00fcsseldorf Germany"},{"name":"Department of Neurology, Medical Faculty Heinrich\u2010Heine\u2010University D\u00fcsseldorf  D\u00fcsseldorf Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Dinkelbach","sequence":"additional","affiliation":[{"name":"Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty Heinrich\u2010Heine\u2010University D\u00fcsseldorf  D\u00fcsseldorf Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon B.","family":"Eickhoff","sequence":"additional","affiliation":[{"name":"Institute of Systems Neuroscience, Medical Faculty Heinrich\u2010Heine\u2010University D\u00fcsseldorf  D\u00fcsseldorf Germany"},{"name":"Institute of Neuroscience and Medicine, Brain &amp; Behaviour (INM\u20107) Research Center J\u00fclich  J\u00fclich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexia Sabine","family":"Moldovan","sequence":"additional","affiliation":[{"name":"Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty Heinrich\u2010Heine\u2010University D\u00fcsseldorf  D\u00fcsseldorf Germany"},{"name":"Department of Neurology, Medical Faculty Heinrich\u2010Heine\u2010University D\u00fcsseldorf  D\u00fcsseldorf Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"S\u00fcdmeyer","sequence":"additional","affiliation":[{"name":"Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty Heinrich\u2010Heine\u2010University D\u00fcsseldorf  D\u00fcsseldorf Germany"},{"name":"Department of Neurology Ernst von Bergmann Hospital  Potsdam Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfons","family":"Schnitzler","sequence":"additional","affiliation":[{"name":"Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty Heinrich\u2010Heine\u2010University D\u00fcsseldorf  D\u00fcsseldorf Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias","family":"Schmidt\u2010Wilcke","sequence":"additional","affiliation":[{"name":"Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty Heinrich\u2010Heine\u2010University D\u00fcsseldorf  D\u00fcsseldorf Germany"},{"name":"Center of Neurology Bezirksklinikum Mainkofen  Deggendorf Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,1,31]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2015.09.020"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31827f0fd1"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26987"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000000707"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2012.1654"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1353-8020(00)00083-3"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2009.07.007"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.10473"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10570"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.42.6.1142"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.55.3.181"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.09.050"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2001.0786"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2014.04.023"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2013.00398"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNN.0000000000000135"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-012-0498-y"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.3171\/2018.11.JNS182908"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-009-5371-4"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh560"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22101"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.64.2.184"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.17.5.427"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3932(94)00104-W"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.61.2.176"}],"container-title":["Journal of Neuroimaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jon.12971","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jon.12971","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jon.12971","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T13:48:38Z","timestamp":1692884918000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jon.12971"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,31]]},"references-count":26,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["10.1111\/jon.12971"],"URL":"https:\/\/doi.org\/10.1111\/jon.12971","archive":["Portico"],"relation":{},"ISSN":["1051-2284","1552-6569"],"issn-type":[{"value":"1051-2284","type":"print"},{"value":"1552-6569","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,31]]},"assertion":[{"value":"2021-09-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}