{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:01:50Z","timestamp":1790834510122,"version":"4.1.0"},"reference-count":53,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,3,28]],"date-time":"2022-03-28T00:00:00Z","timestamp":1648425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Purpose<\/jats:title><jats:p>Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder affecting upper and lower motor neurons. Some ALS patients exhibit concomitant nonmotor signs, and thus ALS is considered a multisystem disorder. The aim of this study is to investigate autonomous nervous system involvement in ALS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We investigated 21 ALS patients and 28 age\u2010matched controls. ALS patients were assessed for disease severity with the Revised\u2010ALS Functional Rating Scale (ALSFSR) and for the presence of autonomic symptoms with the Composite Autonomic Symptom Score scale. Sympathetic nervous system was evaluated by sympathetic skin response (SSR) and parasympathetic nervous system by ultrasonography of vagus nerve (VN) at the level of the thyroid gland.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>SSR latencies were shorter and SSR amplitudes were higher in controls compared to ALS patients. The cross\u2010sectional area (CSA) of the VN was significantly smaller in ALS patients (mean CSA right\/left: 1.73\u00b10.62 mm<jats:sup>2<\/jats:sup>\/1.47\u00b10.53 mm<jats:sup>2<\/jats:sup>) compared to controls (mean CSA right\/left: 2.91\u00b10.79 mm<jats:sup>2<\/jats:sup>\/2.30\u00b10.80 mm<jats:sup>2<\/jats:sup>), right: <jats:italic>p<\/jats:italic> &lt;. 001, left: <jats:italic>p<\/jats:italic> &lt;. 001. There was a significant negative correlation between disease duration and CSA of left\u2010VN (<jats:italic>r<\/jats:italic> = \u20130.493, <jats:italic>p<\/jats:italic> = .023). This correlation was attenuated between disease duration and CSA of right\u2010VN (<jats:italic>r<\/jats:italic> = \u20130.419, <jats:italic>p<\/jats:italic> = .059). ALSFSR\u2010R was positively correlated to CSA of right\u2010VN (<jats:italic>p<\/jats:italic> = .006, <jats:italic>r<\/jats:italic> = 0.590). CSA of VN did not correlate with bulbar involvement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study confirms the presence of autonomic dysfunction in ALS patients and provides evidence of VN atrophy that correlates with disease severity and duration and is independent of bulbar involvement. Degeneration of dorsal nucleus neurons of the VN is hypothesized.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jon.12993","type":"journal-article","created":{"date-parts":[[2022,3,28]],"date-time":"2022-03-28T13:38:51Z","timestamp":1648474731000},"page":"710-719","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Autonomic dysfunction in amyotrophic lateral sclerosis: A neurophysiological and neurosonology study"],"prefix":"10.1111","volume":"32","author":[{"given":"Marianna","family":"Papadopoulou","sequence":"first","affiliation":[{"name":"Department of Physiotherapy Laboratory of Neuromuscular and Cardiovascular Study of Motion University of West Attica  Athens Greece"},{"name":"Second Department of Neurology National and Kapodistrian University of Athens, School of Medicine, Attikon University Hospital  Athens 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