{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T01:47:01Z","timestamp":1793065621373,"version":"4.5.0"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,6,12]],"date-time":"2022-06-12T00:00:00Z","timestamp":1654992000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2022,6,12]],"date-time":"2022-06-12T00:00:00Z","timestamp":1654992000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Purpose<\/jats:title>\n                    <jats:p>Whole\u2010spine magnetic resonance imaging (MRI) studies, to identify structural abnormalities associated with the development of symptomatic spinal stenosis in achondroplasia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Forty\u2010two subjects with achondroplasia were grouped into four age\u2010related categories. Congenital spinal deformities (vertebral body and disc height, interpedicular distance), acquired spinal degenerative changes, thoracic kyphotic (TK) angle, thoracolumbar kyphotic (TLK) angle, spinal canal widths were evaluated by MRI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Patients in the first three groups were asymptomatic and younger (group 1: 4.4\u00a0\u00b1\u00a00.78\u00a0years; group 2: 8.18\u00a0\u00b1\u00a00.60\u00a0years; group 3: 10.95\u00a0\u00b1\u00a00.93\u00a0years) than the symptomatic group (group 4: 23\u00a0\u00b1\u00a01.30\u00a0years). Patients showed height of vertebral bodies, whole canal width, and average lumbar interpedicular distance reduced. Discs degeneration was more pronounced in the lumbar region and in symptomatic adult patients. TK and TLK angles showed a positive correlation with age (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.05,\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a0.42;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.05,\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a0.41), whereas thoracic and thoracolumbar canal width had a negative correlation (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.05,\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a0\u2212.69;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.05,\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a0\u2212.58). A negative correlation between lumbar discs degeneration and canal width was found only at L1\u2010L3 level (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.05,\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a0\u2212.35). At L1\u2010L3, the canal width cutoff value of .59 allowed the differentiation between asymptomatic and symptomatic patients (area under the curve of .966,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.0001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In achondroplasia, the spinal canal narrowing, due to accelerated degenerative changes, is a predisposing factor of symptomatic lumbar spinal stenosis. Lumbar canal MRI is a helpful tool to detect the risk of the development of neurological symptoms; in adult patients, a stenosis higher than 60% of upper lumbar canal could be a critical value for the onset of neurological symptoms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jon.13015","type":"journal-article","created":{"date-parts":[[2022,6,12]],"date-time":"2022-06-12T22:04:30Z","timestamp":1655071470000},"page":"884-893","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Thoracolumbar stenosis and neurologic symptoms: Quantitative MRI in achondroplasia"],"prefix":"10.1111","volume":"32","author":[{"given":"Rosalinda","family":"Calandrelli","sequence":"first","affiliation":[{"name":"Institute of Radiology Fondazione Policlinico Universitario Agostino Gemelli IRCCS  Rome 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