{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T02:35:04Z","timestamp":1793414104963,"version":"4.5.0"},"reference-count":62,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T00:00:00Z","timestamp":1662422400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS060722"],"award-info":[{"award-number":["NS060722"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS082151"],"award-info":[{"award-number":["NS082151"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS112008"],"award-info":[{"award-number":["NS112008"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1 TR002014"],"award-info":[{"award-number":["UL1 TR002014"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000864","name":"Michael J. 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The purpose of this study is to investigate whether structural changes in frontostriatal and limbic pathways contribute to different cognitive trajectories in PD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We obtained clinical and multimodal MRI data from 120 control and 122 PD subjects without dementia or severe motor disability. T1\/T2\u2010weighted images estimated volume, and diffusion imaging evaluated fractional anisotropy (FA) of frontostriatal (striatum and frontostriatal white matter [FSWM]) and limbic (hippocampus and fornix) structures. Montreal Cognitive Assessment (MoCA) gauged total and domain\u2010specific (attention\/executive and memory) cognitive function. Linear mixed\u2010effects models were used to compare MRI and cognitive progression over 4.5\u00a0years between controls and PD and evaluate associations between baseline MRI and cognitive changes in PD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At baseline, control and PD groups were comparable, except PD participants had smaller striatal volume (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). Longitudinally, PD showed faster decline in hippocampal volume, FSWM FA, and fornix FA (<jats:italic>p<\/jats:italic>s\u00a0&lt;\u00a0.016), but not striatal volume (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.218). Total and domain\u2010specific MoCA scores declined faster in PD (<jats:italic>p<\/jats:italic>s\u00a0&lt;\u00a0.030). In PD, lower baseline hippocampal volume (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.005) and fornix FA (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.032), but not striatal volume (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.662) or FSWM FA (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.143), were associated with faster total MoCA decline. Baseline frontostriatal metrics of striatal volume and FSWM FA were associated with faster attention\/executive decline (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.038), whereas lower baseline hippocampal volume was associated with faster memory decline (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.005).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In PD, frontostriatal structural metrics are associated with attention\/executive tasks, whereas limbic changes correlated with faster global cognitive decline, particularly in memory tasks.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jon.13045","type":"journal-article","created":{"date-parts":[[2022,9,7]],"date-time":"2022-09-07T04:55:01Z","timestamp":1662526501000},"page":"121-133","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Frontostriatal and limbic contributions to cognitive decline in Parkinson's disease"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4013-8405","authenticated-orcid":false,"given":"Gregory","family":"Brown","sequence":"first","affiliation":[{"name":"Department of Neurology Penn State University Milton S. Hershey Medical Center  Hershey Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Hakun","sequence":"additional","affiliation":[{"name":"Department of Neurology Penn State University Milton S. Hershey Medical Center  Hershey Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mechelle M.","family":"Lewis","sequence":"additional","affiliation":[{"name":"Department of Neurology Penn State University Milton S. Hershey Medical Center  Hershey Pennsylvania USA"},{"name":"Department of Pharmacology Penn State University Milton S. Hershey Medical Center  Hershey Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sol","family":"De Jesus","sequence":"additional","affiliation":[{"name":"Department of Neurology Penn State University Milton S. Hershey Medical Center  Hershey Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangwei","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Penn State University Milton S. Hershey Medical Center  Hershey Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J.","family":"Eslinger","sequence":"additional","affiliation":[{"name":"Department of Neurology Penn State University Milton S. Hershey Medical Center  Hershey Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences Penn State University Milton S. Hershey Medical Center  Hershey Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuemei","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Neurology Penn State University Milton S. Hershey Medical Center  Hershey Pennsylvania USA"},{"name":"Department of Pharmacology Penn State University Milton S. Hershey Medical Center  Hershey Pennsylvania USA"},{"name":"Department of Public Health Sciences Penn State University Milton S. Hershey Medical Center  Hershey Pennsylvania USA"},{"name":"Department of Neurosurgery Penn State University Milton S. Hershey Medical Center  Hershey Pennsylvania USA"},{"name":"Department of Kinesiology Penn State University Milton S. 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