{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T12:15:15Z","timestamp":1789992915887,"version":"4.0.1"},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,9,9]],"date-time":"2022-09-09T00:00:00Z","timestamp":1662681600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81560223"],"award-info":[{"award-number":["81560223"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81660225"],"award-info":[{"award-number":["81660225"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004607","name":"Natural Science Foundation of Guangxi Province","doi-asserted-by":"publisher","award":["2018GXNSFAA050149"],"award-info":[{"award-number":["2018GXNSFAA050149"]}],"id":[{"id":"10.13039\/501100004607","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Purpose<\/jats:title><jats:p>To investigate the longitudinal alterations of cortical structural\u2010functional coupling (SF coupling) in patients with temporal lobe epilepsy (TLE) over a 2\u2010year follow\u2010up, thereby exploring the neuropathophysiological mechanisms of TLE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010eight TLE patients and 42 age\u2010 and gender\u2010matched healthy controls (HCs) were recruited. We used resting\u2010state functional MRI and diffusion\u2010weighted imaging to estimate and compare SF coupling at the multiscale network level (whole\u2010brain, modular, and regional levels). Then, we analyzed the relationships between the spatial patterns of SF coupling, the principal functional connectivity (FC) gradient, and the functional participation coefficient (PC). Finally, we related regional SF coupling changes between baseline and follow\u2010up to the expression of regional TLE\u2010specific genes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with HCs, TLE patients showed higher baseline SF couplings within the whole\u2010brain, limbic, and default\u2010mode modules. SF couplings within visual and dorsal attention modules were increased at follow\u2010up compared to baseline. In all three groups, the spatial patterns of SF coupling aligned with the principal FC gradient and the functional PC. The longitudinal change in regional SF coupling in TLE patients was significantly positively correlated with the expression of the CUX2 gene.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Aberrant SF coupling was revealed in TLE and related to macroscale cortical hierarchies, functional segregation, and TLE\u2010specific gene expression; these data help increase our understanding of the neuropathophysiological mechanisms underlying TLE.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jon.13046","type":"journal-article","created":{"date-parts":[[2022,9,10]],"date-time":"2022-09-10T03:44:07Z","timestamp":1662781447000},"page":"156-166","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Longitudinal alterations of cortical structural\u2010functional coupling in temporal lobe epilepsy"],"prefix":"10.1111","volume":"33","author":[{"given":"Zexiang","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Neurology The First Affiliated Hospital of Guangxi Medical University  Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binglin","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Neurology The First Affiliated Hospital of Guangxi Medical University  Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linlin","family":"Pang","sequence":"additional","affiliation":[{"name":"Department of Neurology The First Affiliated Hospital of Guangxi Medical University  Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minda","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Neurology The First Affiliated Hospital of Guangxi Medical University  Nanning 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