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The most common stroke mimics include seizure\/epilepsy, migraine with aura, brain tumors, functional disorders, infectious encephalopathies, Wernicke's encephalopathy, and metabolic abnormalities. Brain perfusion imaging techniques, particularly computed tomography perfusion and magnetic resonance perfusion, are being widely used in routine clinical practice for treatment selection in patients presenting with large vessel occlusion. At the same time, the utilization of these imaging modalities enables the opportunity to better diagnose patients with stroke mimics in a time\u2010sensitive setting, leading to appropriate management, decision\u2010making, and resource allocation. In this review, we describe patterns of perfusion abnormalities that could discriminate patients with stroke mimics from those with acute ischemic stroke and provide specific case examples to illustrate these perfusion abnormalities. In addition, we discuss the challenges associated with interpretation of perfusion images in stroke\u2010related pathologies. In general, perfusion imaging can provide additional information in some cases\u2014when used in combination with conventional magnetic resonance imaging and computed tomography\u2014and might help in detecting stroke mimics among patients who present with acute onset focal neurological symptoms.<\/jats:p>","DOI":"10.1111\/jon.13061","type":"journal-article","created":{"date-parts":[[2022,10,8]],"date-time":"2022-10-08T01:53:53Z","timestamp":1665194033000},"page":"44-57","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Clinical application of brain perfusion imaging in detecting stroke mimics: A review"],"prefix":"10.1111","volume":"33","author":[{"given":"Neda","family":"Khalili","sequence":"first","affiliation":[{"name":"Russell H. 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