{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T23:57:55Z","timestamp":1789516675458,"version":"build-2803163510"},"reference-count":50,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,1,10]],"date-time":"2023-01-10T00:00:00Z","timestamp":1673308800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["FOR2438"],"award-info":[{"award-number":["FOR2438"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["TRR241"],"award-info":[{"award-number":["TRR241"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["FDN\u2010167281"],"award-info":[{"award-number":["FDN\u2010167281"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000196","name":"Canada Foundation for Innovation","doi-asserted-by":"publisher","award":["CFI\u2010JELF 38412"],"award-info":[{"award-number":["CFI\u2010JELF 38412"]}],"id":[{"id":"10.13039\/501100000196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Purpose<\/jats:title><jats:p>Novel light\u2010 and sound\u2010based technologies like multispectral optoacoustic tomography (MSOT) with co\u2010registered reflected\u2010ultrasound computed tomography (RUCT) could add additional value to conventional ultrasound (US) for disease phenotyping in pediatric spinal muscular atrophy (SMA). The aim of this study was to investigate the quality of RUCT compared to US for qualitative and quantitative assessment of imaging neuromuscular disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Subanalyzing the MSOT SMA study, 288 RUCT and 276 US images from 10 SMA patients (mean age 9.0\u00a0\u00b1\u00a03.7) and 10 gender\u2010 and age\u2010matched healthy volunteers (HV; mean age 8.7\u00a0\u00b1\u00a04.3) were analyzed for quantitative (grayscale levels [GSLs]) and qualitative (echogenicity, distribution pattern, Heckmatt scale, and muscle texture) muscle changes. RUCT and US measures were further correlated with clinical standard motor outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Quantitative agreement using GSLs revealed significantly higher GSLs in muscles of SMA patients compared to healthy muscles in both techniques (US mean GSL [SD] SMA vs. HV: 110.70 [27.8] vs. 68.85 [19.2], <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.0001; RUCT mean GSL [SD] SMA vs. HV: 91.81 [21.8] vs. 59.86 [8.2], <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.0001) with good correlation with motor outcome tests, respectively. Qualitative agreement between methods for muscle composition was excellent for differentiation of pathological versus healthy muscles, echogenicity, and distribution pattern, moderate for Heckmatt scale, and poor for muscle texture.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The data suggest that RUCT may allow the assessment of basic qualitative and quantitative measures for muscular diseases with comparable results to conventional US.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jon.13081","type":"journal-article","created":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T02:56:27Z","timestamp":1673405787000},"page":"393-403","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Hybrid reflected\u2010ultrasound computed tomography versus B\u2010mode\u2010ultrasound for muscle scoring in spinal muscular atrophy"],"prefix":"10.1111","volume":"33","author":[{"given":"Vera","family":"Danko","sequence":"first","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine, University Hospital Erlangen Friedrich\u2010Alexander\u2010University (FAU) Erlangen\u2010N\u00fcrnberg  Erlangen Germany"},{"name":"Pediatric Experimental and Translational Imaging Laboratory (PETI\u2010Lab), University Hospital Erlangen Friedrich\u2010Alexander\u2010University (FAU) Erlangen\u2010N\u00fcrnberg  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg","family":"J\u00fcngert","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine, University Hospital Erlangen Friedrich\u2010Alexander\u2010University (FAU) Erlangen\u2010N\u00fcrnberg  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Schuessler","sequence":"additional","affiliation":[{"name":"Department of 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Immunotherapy, University Hospital Erlangen Friedrich\u2010Alexander\u2010University (FAU) Erlangen\u2010N\u00fcrnberg  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Federle","sequence":"additional","affiliation":[{"name":"Medical Department 1, University Hospital Erlangen Friedrich\u2010Alexander\u2010University (FAU) Erlangen\u2010N\u00fcrnberg  Erlangen Germany"},{"name":"German Center Immunotherapy, University Hospital Erlangen Friedrich\u2010Alexander\u2010University (FAU) Erlangen\u2010N\u00fcrnberg  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Roos","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology, Developmental Neurology and Social Pediatrics University of Duisburg\u2010Essen  Essen Germany"},{"name":"Children's Hospital of Eastern Ontario Research Institute; Division of Neurology, Department of Medicine, The Ottawa Hospital; and Brain and Mind Research Institute University of Ottawa  Ottawa Canada"},{"name":"Department of Neurology, Heimer Institute for Muscle Research, University Hospital Bergmannsheil Ruhr\u2010University Bochum  Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanns","family":"Lochm\u00fcller","sequence":"additional","affiliation":[{"name":"Children's Hospital of Eastern Ontario Research Institute; Division of Neurology, Department of Medicine, The Ottawa Hospital; and Brain and Mind Research Institute University of Ottawa  Ottawa Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus F.","family":"Neurath","sequence":"additional","affiliation":[{"name":"Medical Department 1, University Hospital Erlangen Friedrich\u2010Alexander\u2010University (FAU) Erlangen\u2010N\u00fcrnberg  Erlangen Germany"},{"name":"German Center Immunotherapy, University Hospital Erlangen Friedrich\u2010Alexander\u2010University (FAU) Erlangen\u2010N\u00fcrnberg  Erlangen 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